Title:
SURFACE-MODIFIED MESOPOROUS SILICA NANOPARTICLE FOR BLOOD-BRAIN BARRIER PENETRATION, TUMOR TARGETING AND CANCER METASTASIS TREATMENT, AND METHODS OF PRODUCTION AND USES THEREOF
Document Type and Number:
Japanese Patent JP2020200306
Kind Code:
A
Abstract:
To provide: mesoporous silica nanoparticles (MSNs) with specific modifications containing both tumor-targeting and blood-brain barrier (BBB) penetration properties suitable for cancer treatment and/or CNS disease treatment; a method of preparing MSNs; and MSNs prepared by the method.SOLUTION: A mesoporous silica nanoparticle having an organic modification with a poly(ethylene glycol) (PEG) moiety and at least one positively charged group-containing oligomer/polymer has a zeta potential in the range from -22 mV to +25 mV at pH 7.4, and a particle size of 50 nm or less.SELECTED DRAWING: None
Inventors:
WU CHENG-HSUN
CHEN YI-PING
WU SI-HAN
MOU CHUNG-YUAN
CHEN YI-PING
WU SI-HAN
MOU CHUNG-YUAN
Application Number:
JP2020080729A
Publication Date:
December 17, 2020
Filing Date:
April 30, 2020
Export Citation:
Assignee:
NANO TARGETING & THERAPY BIOPHARMA INC
International Classes:
A61K47/04; A61K9/14; A61K9/51; A61K31/704; A61K47/10; A61P35/00; A61P35/04; B82Y5/00; B82Y40/00
Attorney, Agent or Firm:
Ebisu International Patent Office