Title:
METHOD FOR LABELING RADIOISOTOPE USING QUINONE COMPOUND, RADIOLABELING COMPOUNDS, AND KIT COMPRISING THE SAME FOR LABELING RADIOISOTOPE
Document Type and Number:
Japanese Patent JP2020200307
Kind Code:
A
Abstract:
To provide a method for labeling a radioisotope having a fast reaction rate even without using an organic solvent, and a labeling kit comprising the same.SOLUTION: In a method for labeling a radioisotope, a cyclooctyne compound represented by the formula (I) to which a biomolecule, a fluorescent dye or a nanoparticle compound is bound is reacted with a quinone compound represented by the formula (II) and labeled with the radioisotope. A kit for labeling a radioisotope comprises the cyclooctyne compound and the quinone compound labeled with the radioisotope.SELECTED DRAWING: Figure 2
Inventors:
PARK SANG HYUN
SAJID MUSHTAQ
CHOI DAE SEONG
SAJID MUSHTAQ
CHOI DAE SEONG
Application Number:
JP2020085636A
Publication Date:
December 17, 2020
Filing Date:
May 15, 2020
Export Citation:
Assignee:
KOREA ATOMIC ENERGY RES
International Classes:
A61K51/00; A61K47/54; A61P35/00
Domestic Patent References:
| JP2013525425A | 2013-06-20 |
Foreign References:
| US20180147288A1 | 2018-05-31 |
Other References:
BORRMANN, ANNIKA, BIOCONJUGATE CHEMISTRY, vol. Vol. 26, Issue 2, JPN6021013942, 18 December 2014 (2014-12-18), pages 257 - 261, ISSN: 0004488048
JEON, JONGHO ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. Vol. 23, Issue 13, JPN6021013943, 1 July 2015 (2015-07-01), pages 3303 - 3308, ISSN: 0004488049
JEON, JONGHO ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. Vol. 23, Issue 13, JPN6021013943, 1 July 2015 (2015-07-01), pages 3303 - 3308, ISSN: 0004488049
Attorney, Agent or Firm:
Mikio Yoshimiya
Toshihiro Kobayashi
Toshihiro Kobayashi