Title:
INHIBITORS OF RET
Document Type and Number:
Japanese Patent JP2021036004
Kind Code:
A
Abstract:
To provide inhibitors of RET.SOLUTION: Described herein are inhibitors of wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions. In another aspect, the present invention provides a method for inhibiting RET activity in a cell or in a patient. In some embodiments, the method comprises the step of bringing the cell into contact with or administering to the patient a compound of the structural formula (I) or a pharmaceutically acceptable salt or composition thereof.SELECTED DRAWING: None
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Inventors:
JASON D BRUBAKER
JOSEPH L KIM
KEVIN J WILSON
DOUGLAS WILSON
LUCIAN V DIPIETRO
JOSEPH L KIM
KEVIN J WILSON
DOUGLAS WILSON
LUCIAN V DIPIETRO
Application Number:
JP2020202520A
Publication Date:
March 04, 2021
Filing Date:
December 07, 2020
Export Citation:
Assignee:
BLUEPRINT MEDICINES CORP
International Classes:
C07D239/30; A61K31/505; A61K31/506; A61P35/00; A61P43/00; C07D239/36; C07D239/38; C07D403/14
Domestic Patent References:
| JP2012529517A | 2012-11-22 | |||
| JP2012521426A | 2012-09-13 | |||
| JP2005535675A | 2005-11-24 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto