Title:
キラル富化二本鎖ＲＮＡ剤
Document Type and Number:
Japanese Patent JP2021507709
Kind Code:
A
Abstract:
本発明は、標的遺伝子の発現を阻害することができるキラル修飾ｄｓＲＮＡ剤に関する。キラル修飾ｄｓＲＮＡ剤のセンス鎖及びアンチセンス鎖は、単独で又は組み合わせて、１つ又は複数の部位特異的−部位特異的／位置特異的キラル修飾ヌクレオチド間結合を含む。
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Inventors:
Manoharan, Musia
Taneja, Nate
Yarns, Hartmut Ingo
Mazda, Shigeo
Charis, Claus
Huh, Guo
Naya, Jayapurakash Kay
Brown, christopher
Schlegel, Mark Kay
Judhab, Vasant
Myr, martin
Taneja, Nate
Yarns, Hartmut Ingo
Mazda, Shigeo
Charis, Claus
Huh, Guo
Naya, Jayapurakash Kay
Brown, christopher
Schlegel, Mark Kay
Judhab, Vasant
Myr, martin
Application Number:
JP2020534493A
Publication Date:
February 25, 2021
Filing Date:
December 21, 2018
Export Citation:
Assignee:
ALNYLAM PHARMACEUTICALS, INC.
International Classes:
C12N15/113; A61K31/7088; A61K48/00; A61P43/00
Domestic Patent References:
| JP2017506911A | 2017-03-16 | |||
| JP2017525705A | 2017-09-07 | |||
| JP2007528367A | 2007-10-11 |
Foreign References:
| WO2017062862A2 | 2017-04-13 | |||
| US20050256069A1 | 2005-11-17 |
Other References:
DRUG DELIVERY SYSTEM, vol. 19, no. 4, JPN6023019077, 2004, pages 348 - 355, ISSN: 0005057102
NAT. BITECHNOL., vol. 35, no. 3, JPN6023019078, March 2017 (2017-03-01), pages 238 - 248, ISSN: 0005057103
NUCLEIC ACIDS RES., vol. 42, no. 22, JPN6023019079, 2014, pages 13456 - 13468, ISSN: 0005057104
NAT. BITECHNOL., vol. 35, no. 3, JPN6023019078, March 2017 (2017-03-01), pages 238 - 248, ISSN: 0005057103
NUCLEIC ACIDS RES., vol. 42, no. 22, JPN6023019079, 2014, pages 13456 - 13468, ISSN: 0005057104
Attorney, Agent or Firm:
Hiroshi Higuchi