Title:
【発明の名称】抗血友病因子(第VIIIc因子)をほとんど含まない高純度のフォン・ヴィレブラント因子を生成する方法
Document Type and Number:
Japanese Patent JP2559645
Kind Code:
B2
Abstract:
The invention relates to a process for manufacturing von Willebrand factor. This process comprises the selective adsorption of factor VIIIc on the gel of a first ion exchange chromatography column, the von Willebrand factor being contained in the non-retained fraction, and is characterised in that the non-retained fraction is treated so as to adsorb the von Willebrand factor selectively on the gel of a second chromatography column, the factor then being desorbed and being obtained with a very high purity. The invention enables a von Willebrand factor of very high purity, largely devoid of antihaemophilic factor VIIIc and of inactivators such as Tween and TNBP, as well as of the main plasm contaminants, to be obtained.
Inventors:
BERUNAARU DAZEI
MOAMU AMUSANI
JERAARU BEZON
MOAMU AMUSANI
JERAARU BEZON
Application Number:
JP19444391A
Publication Date:
December 04, 1996
Filing Date:
August 02, 1991
Export Citation:
Assignee:
ASOSHIASHION DAKITEENU PUURU RU DEV DO RA TORANSUFUYUUJON SANGIN E DE RUSHERUSHU EMATOROJIKU
International Classes:
C07K1/18; C07K1/30; C07K14/435; A61K35/16; C07K14/755; A61K38/00; (IPC1-7): C07K14/755; A61K35/16; C07K1/18; C07K1/30
Domestic Patent References:
| JP3501974A | ||||
| JP63108000A | ||||
| JP1157000A | ||||
| JP60136518A |
Attorney, Agent or Firm:
Kitamura Osamu