Title:
【発明の名称】エイコサトリインアミド-5,8,11化合物,その製造方法および医薬品組成物
Document Type and Number:
Japanese Patent JP2603620
Kind Code:
B2
Abstract:
Processes for preparing 5,8,11-eicosatriynoic acid as well as esters and amides thereof involves initially preparing the acid by reacting 1-decyne with 1,4-dihalo-2-butyne in the presence of a strong base to form 1-halo-2,5-tetradecadiyne which is then reacted with 5-hexynoic acid so as to form 5,8,11-eicosatriynoic acid. This acid can then be converted to the acid chloride form and reacted with an alcohol to form an ester or converted to a potassium salt and reacted with a halide also to form an ester, or after conversion to an acid chloride reacted with an amine in the presence of a tertiary amine to form an amide, or the acid can be reacted with carbonyldiimidazole in the presence of a solvent and excess amine to form an amide.
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Inventors:
Braham Shrouth
Christopher Hensby
Jiyang Meignan
The Eller Lang
Surjiyu Rustol
Michele Koran
Christopher Hensby
Jiyang Meignan
The Eller Lang
Surjiyu Rustol
Michele Koran
Application Number:
JP15777086A
Publication Date:
April 23, 1997
Filing Date:
July 04, 1986
Export Citation:
Assignee:
Center Antel National Drescherche Derma Trojique Garderma Sill Garderma
International Classes:
A61K8/11; A61K8/30; A61K8/33; A61K8/36; A61K8/37; A61K8/42; A61K8/49; A61K8/86; A61K31/16; A61K31/165; A61K31/195; A61K31/20; A61K31/202; A61K8/00; A61K31/22; A61K31/23; A61K31/40; A61K31/445; A61K31/495; A61P17/00; A61P29/00; A61P37/08; A61P43/00; A61Q5/00; A61Q19/00; C07C17/26; C07C51/353; C07C57/18; C07C57/68; C07C67/00; C07C69/606; C07C231/00; C07C231/02; C07C233/02; C07C233/09; C07C233/16; C07C233/20; C07D295/16; C07D295/18; C07D295/185; C07D317/20; C12N9/99; (IPC1-7): C07C57/18; A61K31/16; A61K31/165; A61K31/22; A61K31/23; A61K31/40; A61K31/495; C07C51/353; C07C69/606; C07C231/02; C07C233/09; C07C233/20; C07D295/18
Attorney, Agent or Firm:
Akira Asamura (2 outside)