【発明の名称】ヘパリン誘導体

Japanese Patent JP2643950

B2

The present invention is directed to a number of different derivatives of heparin and low molecular weight heparin. These include acetyl ester derivatives of heparin and ester derivatives of low molecular weight heparin which exhibit improved anti-Xa activity in relation to global anticlotting activity. Also disclosed are ester derivatives of heparin exhibiting low anti-Xa activity in relation to global anticlotting activity. Further disclosed are heparin derivatives and low molecular weight heparin derivatives containing hydrophobic groups and exhibiting improved permeability and which further exhibit anticoagulant activity and improved solubility in organic solvents.

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KEBIN MAIKURU FUORII
CHAARUZU KYANBURU GURIFUIN
EDOWARUDO AMAYA

JP20735987A

August 25, 1997

August 20, 1987

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MAIAMI UNIV

A61K31/715; A61P7/02; C08B37/10; C08B37/00; (IPC1-7): C08B37/10; A61K31/725

JP52111983A
JP55158055A

Yoshio Kawaguchi (2 outside)

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