Title:
【発明の名称】端が切り取られた軽鎖を有する組換えプロテインC
Document Type and Number:
Japanese Patent JP3153236
Kind Code:
B2
Abstract:
Methods are disclosed for producing a protein which has the biological activity of human activated protein C. The protein is produced by mammalian host cells transfected with a plasmid capable of integration in mammalian host cell DNA. The plasmid includes a promoter followed downstream by a nucleotide sequence which encodes an activated protein C precursor that is processed to yield a protein having substantially the activity of human activated protein C, wherein the light chain of the active protein contains 149 amino acid residues.
Inventors:
Foster, Donald Sea.
Holly, Richard Dee.
Kumar, Anor Ashok
Masahiko Suzuki
Kenji Wakabayashi
Holly, Richard Dee.
Kumar, Anor Ashok
Masahiko Suzuki
Kenji Wakabayashi
Application Number:
JP50434191A
Publication Date:
April 03, 2001
Filing Date:
December 21, 1990
Export Citation:
Assignee:
Zymogenetics, Incorporated
Teijin Limited
Teijin Limited
International Classes:
A61K38/46; A61P7/02; C07K14/00; C07K14/435; C07K14/47; C07K19/00; C12N5/10; C12N9/64; C12N15/09; C12N15/57; C12P21/02; C12R1/91; (IPC1-7): C12N15/09; C12N5/10; C12P21/02
Domestic Patent References:
| JP6485096A |
Other References:
【文献】欧州特許出願公開319944(EP,A2)
Attorney, Agent or Firm:
Aoki Akira (2 outside)