Title:
【発明の名称】ブラジキニン型ペプチド
Document Type and Number:
Japanese Patent JP3465000
Kind Code:
B2
Abstract:
The substitution of the L-Pro at the 7-position with D-Phe or D-Tic and substitution of the L-Phe at the 8-position with hydroxyproline ethers and thioethers of the peptide hormone bradykinin and other additional substituted analogs of bradykinin converts bradykinin agonists into bradykinin antagonists. The invention further includes additional modifications at other positions within the novel 7- and 8-position modified bradykinin antagonists, which increase enzyme resistance, antagonist potency, and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of a mammal and human in which an excess of bradykinin or related kinins are produced or injected as by insect bites.
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Inventors:
Keel donald james
Heiner Roger Neal
Heiner Roger Neal
Application Number:
JP51139592A
Publication Date:
November 10, 2003
Filing Date:
April 16, 1992
Export Citation:
Assignee:
Sios Nova Incorporated
International Classes:
A61K38/00; A61P17/00; A61P17/02; A61P25/04; A61P29/00; C07D207/12; C07K7/14; A61K38/17; C07K7/18; (IPC1-7): C07K7/14; A61K38/00; A61K38/17; A61P17/00; A61P17/02; A61P25/04; A61P29/00
Domestic Patent References:
| JP2184697A |
Other References:
Ｊ．Ｍｅｄ．Ｃｈｅｍ．，１９８８年，Ｖｏｌ．３１，ｐｐ．１１４８−１１６０
Ｊ．Ｍｅｄ．Ｃｈｅｍ．，１９９１年 ３月，Ｖｏｌ．３４，ｐｐ．１２３０−１２３３
Ｊ．Ｍｅｄ．Ｃｈｅｍ．，１９９１年 ３月，Ｖｏｌ．３４，ｐｐ．１２３０−１２３３
Attorney, Agent or Firm:
Miyao Ichinose