Title:
胃酸分泌を阻害するイミダゾピリジン誘導体
Document Type and Number:
Japanese Patent JP3692034
Kind Code:
B2
Abstract:
Imidazopyridine derivatives (I) are new. Imidazopyridine derivatives of formula (I) having a molecular weight of at most 600 and their salts are new: [Image] R 1>H, Me or CH 2OH; R 2>Me or Et; R 3>, R 4>H, 1-6C alkyl, 1-6C hydroxyalkyl or halo; R 5>H or halo; X : NH or O; R 7>, R 6>substituents comprising C, H, N, O, S, Se, P or halo; provided that at least one of R 6> and R 7> is not H, 1-6C alkyl, 1-6C hydroxyalkyl or 1-6C alkoxy-1-6C alkyl; Independent claims are included for the following: (a) composition comprising (I) and at least an antimicrobial agent (II) or proton pump inhibitor (III) for simultaneous, separate or sequential use in the prevention or treatment of gastrointestinal inflammatory diseases; (b) preparation of (I); and (c) intermediate compounds of formulae (IV), (V) and (VI). [Image] R 9>H, CH 3 or an ester group; and R x>an ester group. NB The positions of R 4> and R 5> in (I) are different in (V) and (VI). ACTIVITY : Antiinflammatory. MECHANISM OF ACTION : Gastric acid secretion inhibitor.
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Inventors:
Kosrat Amin
Michael Dahlström
Peter Nordberg
Ingemar Starke
Michael Dahlström
Peter Nordberg
Ingemar Starke
Application Number:
JP2000545865A
Publication Date:
September 07, 2005
Filing Date:
April 23, 1999
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
A61K31/435; A61K31/437; A61K31/496; C07D471/04; A61K31/5355; A61P1/00; A61P1/04; (IPC1-7): C07D471/04; A61K31/437; A61P1/04
Domestic Patent References:
| JP1151579A | ||||
| JP56113782A | ||||
| JP62016483A | ||||
| JP2002513024A |
Foreign References:
| US4767755 | ||||
| US4990506 |
Other References:
J. Med.Chem.,1985年,Vol.28,No.7,p876-892
Attorney, Agent or Firm:
Chika Takagi
Kosuke Nishimura
Kosuke Nishimura