Title:
ジアセチルレインの精製方法
Document Type and Number:
Japanese Patent JP3782109
Kind Code:
B2
Abstract:
PCT No. PCT/IB96/00093 Sec. 371 Date Mar. 18, 1997 Sec. 102(e) Date Mar. 18, 1997 PCT Filed Feb. 7, 1996 PCT Pub. No. WO96/24572 PCT Pub. Date Aug. 15, 1996The present invention discloses a method for preparing purified diacetylrhein to be used in the preparation of drugs which includes the steps of: (a) suspending a diacetylrhein containing various impurities and, in particular, relatively high amounts of aloe-emodin derivatives, in a mixture of organic solvent/water; (b) adding a tertiary amine; (c) adding to the solution obtained a salt of an acid and of an alkali metal or of an alkaline-earth metal; (d) carrying out a hydrolysis in a weakly acidic medium; (e) collecting the purified diacetylrhein, by filtration.\!
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Inventors:
Avenham, Cohen
Application Number:
JP52410796A
Publication Date:
June 07, 2006
Filing Date:
February 07, 1996
Export Citation:
Assignee:
Litwen Trading Limited
International Classes:
A61K36/48; A61K31/19; C07C69/16; A61K31/22; A61K36/00; A61K36/896; A61P19/02; A61P43/00; C07C67/52; C07C67/60; C07C69/00
Domestic Patent References:
| JP6502190A | ||||
| JP638354A | ||||
| JP5186394A |
Attorney, Agent or Firm:
Tadahiko Ito