Title:
組織特異的および標的RNA特異的リボザイム
Document Type and Number:
Japanese Patent JP4033902
Kind Code:
B2
Abstract:
The invention provides tissue-specific and target RNA-specific ribozymes. These ribozymes can be used to destroy target-specific neoplasms and to treat viral infections, among other uses. The ribozymes of the present invention comprise a 5' autocatalytically cleaving ribozyme sequence, a catalytic ribozyme comprising a target RNA-specific binding site and a 3' autocatalytically cleaving ribozyme. The invention also provides nucleic acids which encode the ribozymes of the invention. These nucleic acids can be used to express the ribozymes of the invention at the selected site. Methods of treating disease by administering the ribozymes are provided.
Inventors:
Norris, James S.
Crowson, Gerry A.
Crowson, Gerry A.
Application Number:
JP51838197A
Publication Date:
January 16, 2008
Filing Date:
November 08, 1996
Export Citation:
Assignee:
MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Penn State Research Foundation
Penn State Research Foundation
International Classes:
A01K67/027; A61K31/00; C12N15/09; A61K48/00; A61P31/00; A61P31/12; A61P35/00; A61P43/00; C12N5/10; C12N9/00; C12N15/113; C12N15/88; A61K38/00
Domestic Patent References:
| JP5192151A |
Attorney, Agent or Firm:
Hidesaku Yamamoto