Title:
TIE-2リガンド、その作製方法および使用方法
Document Type and Number:
Japanese Patent JP4054375
Kind Code:
B2
Abstract:
The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.
Inventors:
Davis, Samuel
Brno, Joan
Gold ferb, mitchell
Aldrich, Thomas H.
Mason Piare, Peter Sea.
Radzijewski, Cheslow
Jones, Pamela F.
Jan Kopoulos, George Dee.
Brno, Joan
Gold ferb, mitchell
Aldrich, Thomas H.
Mason Piare, Peter Sea.
Radzijewski, Cheslow
Jones, Pamela F.
Jan Kopoulos, George Dee.
Application Number:
JP51267296A
Publication Date:
February 27, 2008
Filing Date:
October 06, 1995
Export Citation:
Assignee:
Regeneron Pharmaceuticals, Inc.
International Classes:
C12N15/09; A61K38/00; G01N33/50; A61K38/17; A61K39/395; A61K47/48; A61K48/00; A61K51/00; A61P9/10; A61P29/00; A61P31/04; A61P35/00; C07H21/04; C07K14/47; C07K14/515; C07K14/705; C07K16/28; C07K19/00; C12N5/06; C12N5/10; C12N15/00; C12N15/02; C12N15/12; C12N15/19; C12N15/62; C12N15/63; C12P21/02; C12P21/08; G01N33/53; C12R1/91; C07K; C12N
Other References:
Oncogene, 1993年, Vol.8, p.1631-1637
Attorney, Agent or Firm:
Hidesaku Yamamoto