Title:
リポキシゲナーゼ阻害剤
Document Type and Number:
Japanese Patent JP4231559
Kind Code:
B2
Abstract:
Novel inhibitors of the enzyme action of lipoxygenase, especially 5-lipoxygenase and 12-lipoxygenase that are derived from the extraction of the seeds of the perilla (crispa) or perilla (frutescens) plant. These inhibitors are suitably extracted from these seeds using alcohol, preferably ethanol, to form an extract or more preferably to further extract the alcoholic extract with ethyl acetate and water to partition the active inhibitors to the ethyl acetate. The particularly preferred inhibitors are luteolin and chrysoeriol.
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Inventors:
Hiroyo Yamamoto
Okada Tadashi
Hiromichi Murai
Okada Tadashi
Hiromichi Murai
Application Number:
JP10595997A
Publication Date:
March 04, 2009
Filing Date:
April 23, 1997
Export Citation:
Assignee:
Oriza Yuka Co., Ltd.
International Classes:
A61K36/53; A61K31/192; C12N9/99; A61K31/216; A61K31/35; A61K31/352; A61K36/00; A61K36/535; A61P29/00; A61P37/08; A61P43/00; C07D311/30
Domestic Patent References:
| JP4208221A | ||||
| JP55057583A | ||||
| JP63233917A |
Other References:
Baumann,J. et al,Flavonoids and related compounds as inhibitors of arachidonic acid peroxidation, Prostaglandins ,1980年,Vol.20,No.4,pp.627-639,Table 1
Robak, Jadwiga et al ,Screening of the influence of flavonoids on lipoxygenase and cyclooxygenase activity, as well as on nonenzymic lipid oxidation, PolishJournal of Pharmacology and Pharmacy ,1988年,Vol.40,No.5,pp.451-458,Table 2
Ishikura, Nariyuki,Anthocyanins and flavones in leaves and seeds of Perilla plant,Agricultural and Biological Chemistry ,1981年,Vol.45,No.8,pp.1855-1860
YANOSHITA R.et al,Inhibition of lysoPAF acetyltransferase activity by flavonoids,Inflamm Res ,1996年,Vol.45,No.11,Page.546-549
Middleton,Elliott,Jr.,Middleton, Elliott, Jr,Planta Medica ,1987年,Vol.53,No.4,pp.325-328,Table I
Robak, Jadwiga et al ,Screening of the influence of flavonoids on lipoxygenase and cyclooxygenase activity, as well as on nonenzymic lipid oxidation, PolishJournal of Pharmacology and Pharmacy ,1988年,Vol.40,No.5,pp.451-458,Table 2
Ishikura, Nariyuki,Anthocyanins and flavones in leaves and seeds of Perilla plant,Agricultural and Biological Chemistry ,1981年,Vol.45,No.8,pp.1855-1860
YANOSHITA R.et al,Inhibition of lysoPAF acetyltransferase activity by flavonoids,Inflamm Res ,1996年,Vol.45,No.11,Page.546-549
Middleton,Elliott,Jr.,Middleton, Elliott, Jr,Planta Medica ,1987年,Vol.53,No.4,pp.325-328,Table I
Attorney, Agent or Firm:
Yoshifumi Matsunami