Title:
新規ビタミンD構造類似体
Document Type and Number:
Japanese Patent JP4235256
Kind Code:
B2
Abstract:
The present invention relates to analogues of vitamin D, which lack the combined presence of the trans-fused six-membered C-ring and of five-membered D-ring, but still possess a central part consisting of a substituted chain of five atoms, atoms which correspond to positions 8, 14, 13, 17 and 20 of vitamin D, and at the ends of which are connected, at position 20 a structural moiety representing part of the side-chain of vitamin D or of an analogue of vitamin D, and at position 8 the DELTA (5,7)-diene moiety connected to the A-ring of the active 1-alpha-hydroxy metabolite or of an established vitamin D analogue, to their preparation process, to pharmaceutical preparations comprising these compounds and to their use in medicine.
Inventors:
Bouillon, Roger
Vandewale, Mauriz
De Clerco, Pierre Jean
Vandewale, Mauriz
De Clerco, Pierre Jean
Application Number:
JP50383595A
Publication Date:
March 11, 2009
Filing Date:
July 07, 1994
Export Citation:
Assignee:
K.U.LEUVEN RESEARCH & DEVELOPMENT
Roger BOUILLON
Universiteit Gent
Roger BOUILLON
Universiteit Gent
International Classes:
A61K31/59; A61K31/045; C07C401/00; A61K31/075; A61P17/00; A61P19/10; A61P29/00; A61P35/00; A61P43/00; C07C35/22; C07C35/27; C07C43/188; C07C45/28; C07C47/192; C07C47/198; C07C47/347; C07C47/36; C07C47/37; C07C49/242; C07C49/517; C07C49/523; C07C49/687; C07C49/743; C07C49/755; C07C57/26; C07C59/01; C07C61/13; C07C69/18; C07C69/21; C07C69/757; C07C255/47
Domestic Patent References:
| JP4505332A | ||||
| JP5140090A | ||||
| JP3505330A | ||||
| JP61501146A |
Foreign References:
| DE3913310A |
Other References:
Tetrahedron Letters, 1990年,31(13), p.1823-1824
Tetrahedron Letters, 1992年,33(21), p.2937-2940
Tetrahedron Letters, 1992年,33(21), p.2937-2940
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi