Title:
2-アミノ-4,5-三置換チアゾリル誘導体
Document Type and Number:
Japanese Patent JP4388805
Kind Code:
B2
Abstract:
This invention concerns the use of a compound of formula (I′) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z is halo; C1-6alkyl; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; aminocarbonyl; C1-6alkyl substituted with hydroxy, carboxyl, cyano, amino, amino substituted with piperidinyl, amino substituted with C1-4alkyl substituted piperidinyl, mono- or di(C1-6alkyl)amino, aminocarbonyl, mono- or di(C1-6alkyl)aminocarbonyl, C1-6alkyloxycarbonyl, C1-6alkyloxy, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl; polyhaloC1-4alkyl; cyano; amino; mono- or di(C1-6alkyl)aminocarbonyl; C1-6alkyloxycarbonyl; C1-6alkylcarbonyloxy; aminoS(═O)2—; mono- or di(C1-6alkyl)aminoS(═O)2; —C(═N—Rx)NRyRz; Q is optionally substituted C3-6cycloalkyl, phenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, benzthiazolyl, benzoxazolyl, benzimidazolyl, indazolyl, or imidazopyridyl, or Q is a radical of formula L is optionally substituted phenyl or an optionally substituted monocyclic 5 or 6-membered partially saturated or aromatic heterocycle or a bicyclic partially saturated or aromatic heterocycle; aryl is optionally substituted phenyl; for the manufacture of a medicament for the prevention or the treatment of inflammatory and/or auto-immune diseases mediated through TNF-α and/or IL-12.
Inventors:
Love, Christopher Jiyoung
Van Lomen, Guy Rosalia Eugene
Doyon, Giulian Giorgiuil Pierre-Olivier
Bongartz, Jean-Pierre André Marc
Van der Ahe, Marcel Joseph Maria
Hendrix, Robert Joseph Maria
Buinsters, Peter Jacobs Johannes Antonius
Koiman, Ludwig Paul
Bander Messen, Nell
Kesman, Elvin
Bex, Gustav Maria
Van Lomen, Guy Rosalia Eugene
Doyon, Giulian Giorgiuil Pierre-Olivier
Bongartz, Jean-Pierre André Marc
Van der Ahe, Marcel Joseph Maria
Hendrix, Robert Joseph Maria
Buinsters, Peter Jacobs Johannes Antonius
Koiman, Ludwig Paul
Bander Messen, Nell
Kesman, Elvin
Bex, Gustav Maria
Application Number:
JP2003520732A
Publication Date:
December 24, 2009
Filing Date:
August 09, 2002
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D417/04; A61K31/425; A61K31/429; A61K31/437; A61K31/4439; A61K31/4545; A61K31/5377; A61P29/00; A61P33/00; A61P35/00; A61P37/00; A61P43/00; C07D277/42; C07D417/14; C07D471/04; C07D513/04
Domestic Patent References:
| JP7149745A | ||||
| JP62067022A | ||||
| JP61010557A | ||||
| JP2003525291A |
Foreign References:
| WO2002034748A1 |
Other References:
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry,1979年,18B(4),384-386
Journal of the Indian Chemical Society,1975年,52(8),740-742
Journal of the Indian Chemical Society,1971年,48(7),665-668
Journal of the Indian Chemical Society,1975年,52(8),740-742
Journal of the Indian Chemical Society,1971年,48(7),665-668
Attorney, Agent or Firm:
Patent business corporation Odashima patent office