Title:
妊娠関連血漿蛋白-A2(PAPP-A2)
Document Type and Number:
Japanese Patent JP4460829
Kind Code:
B2
Abstract:
The present invention provides nucleotide and amino acid sequences that identify and encode a new protein with homology to pregnancy-associated plasma protein-A (PAPP-A). We denote this protein PAPP-A2. The cDNA encoding PAPP-A2 was derived from human placenta. The present invention also provides for antisense molecules to the nucleotide sequences which encode PAPP-A2, expression vectors for the production of purified PAPP-A2, antibodies capable of binding specifically to PAPP-A2, hybridization probes or oligonucleotides for the detection of PAPP-A2-encoding nucleotide sequences, genetically engineered host cells for the expression of PAPP-A2, use of the protein to produce antibodies capable of binding specifically to the protein, methods for screening for pathologies in pregnant and non-pregnant patients that are based on detection of PAPP-A2 antigen in human body fluids or PAPP-A2-encoding nucleic acid molecules, use of the protein to screen for agents that alter the protease activity of PAPP-A2, use of the protein as a therapeutic target for such agents, and use of the protein as a therapeutic agent in relevant pathological states. Methods for screening for altered focal proliferation states in pregnant and/or non-pregnant patients, which include detecting levels of PAPP-A2, are also described. The present invention also provides the identification of a natural substrate of PAPP-A2, insulin-like growth factor binding protein (IGFBP)-5.
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Inventors:
Klaus Oxwig
Michael Toft Overgod
Michael Toft Overgod
Application Number:
JP2002536334A
Publication Date:
May 12, 2010
Filing Date:
October 19, 2001
Export Citation:
Assignee:
Como Biotech ApS
International Classes:
A01K67/027; C12N15/09; A61K31/7088; A61K35/12; A61K38/00; A61K45/00; A61K48/00; A61P9/10; A61P19/02; A61P19/10; A61P29/00; A61P35/00; A61P43/00; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/64; C12P21/08; C12Q1/02; C12Q1/37; C12Q1/68; G01N21/77; G01N21/78; G01N33/15; G01N33/50; G01N33/53; G01N33/566; G01N33/577; G01N33/68
Other References:
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Proc. Natl.Acad. Sci. USA.,1999年,Vol.96, No.6,pp.3149-3153
Clin. Chem.,1997年,Vol.43, No.12,pp.2323-2332
Clin. Chem.,2000年,Vol.46, No.8,pp.1099-1105
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita