Title:
インドール誘導体
Document Type and Number:
Japanese Patent JP4460830
Kind Code:
B2
Abstract:
Compounds of formula (I) or salts or solvates thereof or physiologically functional derivatives thereof are potent binders at the EP4 receptor and are of use in the treatment or prevention of conditions such as a pain, inflammatory, immunological, bone, neurodegenerative or renal disorder.
More Like This:
Inventors:
Demain, derrick, anthony
Giblin, Gerrard, Martin, Paul
Hoskin, Rachel, Elizabeth
Inglis, Graham, George, Adam
Rewell, Xiao, King
McDonald's, Simon, John, Fawsett
Mason, Andrew, McMurtry
Swerbrick, martin, edward
Giblin, Gerrard, Martin, Paul
Hoskin, Rachel, Elizabeth
Inglis, Graham, George, Adam
Rewell, Xiao, King
McDonald's, Simon, John, Fawsett
Mason, Andrew, McMurtry
Swerbrick, martin, edward
Application Number:
JP2002551528A
Publication Date:
May 12, 2010
Filing Date:
December 20, 2001
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
C07D209/18; C07D403/04; A61K31/405; A61K31/42; A61K31/422; A61P1/00; A61P1/02; A61P1/14; A61P3/10; A61P9/00; A61P11/00; A61P19/02; A61P19/06; A61P19/10; A61P21/00; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/28; A61P27/02; A61P29/00; A61P31/12; A61P35/00; A61P37/00; A61P37/02; A61P43/00; C07D407/04; C07D409/04; C07D413/04
Domestic Patent References:
| JP62138469A | ||||
| JP11504040A | ||||
| JP11071336A | ||||
| JP4247080A | ||||
| JP2000516958A |
Foreign References:
| WO2000006550A1 | ||||
| WO2002053534A1 | ||||
| WO2000018744A1 | ||||
| WO2000021532A1 | ||||
| WO2002016311A1 |
Other References:
Sisto, Alessandro,Synthesis and biological evaluation of novel NK-1 tachykinin receptor antagonists: the use of cycloalkyl amino acids as a template,Biopolymers,1995年,Vol.36,No.4,p.511-24
El-Gendy, A. A.,Synthesis of 3-indoleacetyl derivatives of certain amino and phenolic compounds likely to possess antiinflammatory activity,Pharmazie,1982年,Vol.37,No.7,p.481-2
Schlittler, E.,The ring structure of yohimbine. II. Ketoyobyrine,Helvetica Chimica Acta,1948年,Vol.31,p.1199-1205
Naito, Kakeo,Hydrogenation of 18-methoxy-15,16,17,18,19,20-hexahydroyohimban. I. Synthesis of dl-18-oxo-Δ15(20)-yohimbene,Yakugaku Zasshi,1960年,Vol.80,p.629-31
Merlini, Lucio,Gambier alkaloids. Relation between ourouparine and gambiertannins and synthesis of oxogambiertannin,Gazzetta Chimica Italiana,1967年,Vol.97,No.12,p.1915-20
Edwards, O. E.,The structure of sempervirine,Journal of the American Chemical Society,1949年,Vol.71,p.1694-6
Potts, K. T.,Synthetic experiments related to the indole alkaloids,Journal of the Chemical Society,1955年,p.2675-86
El-Gendy, A. A.,Synthesis of 3-indoleacetyl derivatives of certain amino and phenolic compounds likely to possess antiinflammatory activity,Pharmazie,1982年,Vol.37,No.7,p.481-2
Schlittler, E.,The ring structure of yohimbine. II. Ketoyobyrine,Helvetica Chimica Acta,1948年,Vol.31,p.1199-1205
Naito, Kakeo,Hydrogenation of 18-methoxy-15,16,17,18,19,20-hexahydroyohimban. I. Synthesis of dl-18-oxo-Δ15(20)-yohimbene,Yakugaku Zasshi,1960年,Vol.80,p.629-31
Merlini, Lucio,Gambier alkaloids. Relation between ourouparine and gambiertannins and synthesis of oxogambiertannin,Gazzetta Chimica Italiana,1967年,Vol.97,No.12,p.1915-20
Edwards, O. E.,The structure of sempervirine,Journal of the American Chemical Society,1949年,Vol.71,p.1694-6
Potts, K. T.,Synthetic experiments related to the indole alkaloids,Journal of the Chemical Society,1955年,p.2675-86
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Satoshi Fujita
Eiichi Arai