Title:
グルタミン産生能を有する新規のBifidobacterium菌株
Document Type and Number:
Japanese Patent JP4540664
Kind Code:
B2
Abstract:
Strains of Bifidobacterium having the ability to survive in the intestinal tract and to produce glutamine in vivo, is new. Independent claims are included for the following: (1) one or more of (I) belonging to the species Bifidobacterium infantis for use in therapy; (2) a composition (II) comprising one or more of (I), in combination with a carrier; and (3) use of one or more of (I), for the preparation of a medicament for treatment of intensive care patients with multiple organ dysfunction and intestinal failure, for prophylaxis in chemotherapy patients and patients with inflammatory diseases, or for postoperative administration after major surgery. ACTIVITY : Gastrointestinal-Gen; Hepatoprotective; Antiinflammatory. MECHANISM OF ACTION : Producer of glutamine and arginine in vivo. Effects of Bifidobacterium strains on dextran sodium sulfate (DDS) induced colitis in rat was tested. Sprague dawley rates were administered orally with different strains of Bifidobacterium for 7 days prior to the induction of colitis (day 0) and were continuously administered for 7 days in combination with DDS (5% w/v dissolved in water). The degree of colitis were determined daily with disease activity index (DAI). Sampling was performed on day 14 and bacterial translocation and quantity in the intestine was determined. DAI was significantly lower in the group receiving B.infantis CURE 19 compared to the groups receiving Lactobacillus paracasei 8700:2 and L.gasseri LG1. After 6 and 7 days, orally administered bacterial strains were able to exercise positive effects by decreasing translocation on experimental colitis in rats. CURE 19 was more effective in counteracting the colitis than the others.
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Inventors:
Morin Golan
Artistic
Japson bent
Artistic
Japson bent
Application Number:
JP2006502776A
Publication Date:
September 08, 2010
Filing Date:
January 27, 2004
Export Citation:
Assignee:
Probi AB
International Classes:
C12N1/20; A23L1/30; A23L29/00; A61K35/74; A61K45/00; A61P1/14; A61P1/16; A61P3/00; A61P13/12; A61P25/00; A61P25/32; A61P29/00; A61P31/00; A61P39/00; A61P41/00; A61P43/00; C12N15/09; C12N
Domestic Patent References:
| JP2002534113A | ||||
| JP2005508617A | ||||
| JP7126177A | ||||
| JP59155321A | ||||
| JP9227391A | ||||
| JP2002335860A | ||||
| JP2002186422A |
Foreign References:
| FR2560046A1 | ||||
| WO2002102168A1 | ||||
| WO2002062360A1 | ||||
| WO2002060276A1 |
Other References:
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Jap. J. Dairy Food Sci.,1990年,Vol.39, No.6,pp.A229-A237
Agric. Biol. Chem.,1987年,Vol.51, No.2,pp.425-433
Int. Dairy Jour.,2000年,Vol.10,pp.401-408
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Agric. Biol. Chem.,1987年,Vol.51, No.1,pp.251-252
化学と生物,1993年,Vol.31, No.10,pp.639-649
Jap. J. Dairy Food Sci.,1990年,Vol.39, No.6,pp.A229-A237
Agric. Biol. Chem.,1987年,Vol.51, No.2,pp.425-433
Int. Dairy Jour.,2000年,Vol.10,pp.401-408
Ann. Microbil.,1978年,Vol.129 B,pp.175-181
Agric. Biol. Chem.,1987年,Vol.51, No.1,pp.251-252
化学と生物,1993年,Vol.31, No.10,pp.639-649
Attorney, Agent or Firm:
Eiji Saegusa
Kakehi Yuro
Kenji Saito
Kakehi Yuro
Kenji Saito