Title:
α-1-リン酸化2-デオキシ-2-フルオロアラビノシド及び2’-デオキシ-2’-フルオロ-β-D-アラビノヌクレオシドの製造法
Document Type and Number:
Japanese Patent JP4658807
Kind Code:
B2
Abstract:
A method for producing 2'-deoxy-2'-fluoro-²-D-arabinonucleoside represented by formula (II):
(wherein B represents a base), in particular, 2'-deoxy-2'-fluoro-²-D-arabinopurinenucleoside, which method comprises causing a nucleoside phosphorylase to act on ±-1-phosphorylated-2-deoxy-2-fluoroarabinoside represented by formula (I):
or a mixture of ±- and ²-isomers of 1-phosphorylated-2-deoxy-2-fluoroarabinoside represented by formula (V'):
and on a base. The compound can be produced at high yield and in a convenient and highly stereoselective manner.
Inventors:
Kohei Yamada
Matsumoto Rinuki
Hiroyuki Hayakawa
Matsumoto Rinuki
Hiroyuki Hayakawa
Application Number:
JP2005514979A
Publication Date:
March 23, 2011
Filing Date:
October 22, 2004
Export Citation:
Assignee:
Yamasa Shoyu Co., Ltd.
International Classes:
C07H11/04; C07H1/02; C07H19/19; C12P19/40; C12P41/00
Domestic Patent References:
| JPS62161797A | 1987-07-17 | |||
| JP2002205996A | 2002-07-23 |
Foreign References:
| WO1999067378A1 | 1999-12-29 | |||
| WO1999057895A1 | 1999-11-11 |
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
Hiromi Matoba
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
Hiromi Matoba