Title:
不死化された抗体分泌細胞の製造方法
Document Type and Number:
Japanese Patent JP4695840
Kind Code:
B2
Abstract:
A method for producing immortalized antibody-secreting cells, comprising: (a) providing a transgenic animal having antibody-secreting cells capable of expressing one or more transgenes, wherein the antibody-secreting cells are in a non-immortalized state in the absence of a stimulus and are capable of changing to an immortalized state by means of the transgene or transgenes upon exposure of the cells to the stimulus; (b) extracting the antibody-secreting cells from the animal; and (c) exposing the antibody-secreting cells to the stimulus, thereby immortalizing the antibody secreting cells by means of the transgene or transgenes.
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Inventors:
Jason Peter Brown
Application Number:
JP2003586342A
Publication Date:
June 08, 2011
Filing Date:
April 16, 2003
Export Citation:
Assignee:
Granta Biotechnology Limited
International Classes:
C12N15/09; A01K67/027; C07K14/705; C07K14/82; C07K16/00; C07K16/32; C12N5/10; C12N15/85; C12P21/08
Domestic Patent References:
| JP10506266A |
Foreign References:
| WO2000009669A1 |
Other References:
Immunology Letters,1999年,vol.65,p.153-159
THEISEN MANFRED,STRATEGIES IN TRANSGENIC ANIMAL SCIENCE.,米国,AMERICAN SOCIETY FOR MICROBIOLOGY,1995年,P311-324,(ASM) BOOKS DIVISION
PAVIRANI A,BIO/TECHNOLOGY,米国,NATURE PUBLISHING CO.,1989年10月 1日,V7 N10,P1049-1054
THEISEN MANFRED,STRATEGIES IN TRANSGENIC ANIMAL SCIENCE.,米国,AMERICAN SOCIETY FOR MICROBIOLOGY,1995年,P311-324,(ASM) BOOKS DIVISION
PAVIRANI A,BIO/TECHNOLOGY,米国,NATURE PUBLISHING CO.,1989年10月 1日,V7 N10,P1049-1054
Attorney, Agent or Firm:
Koichi Hirota
Yoshihiro Nagare
Naoko Matsuda
Yoshihiro Nagare
Naoko Matsuda