Title:
タンパク質抗原およびペプチド抗原の免疫原性を増強するためのFC融合タンパク質
Document Type and Number:
Japanese Patent JP4764585
Kind Code:
B2
Abstract:
Disclosed herein are methods and compositions for enhancing the immunogenicity of a preselected protein or peptide antigen in a mammal. Immunogenicity is enhanced by fusing the preselected antigen to an immunoglobulin heavy chain constant region to produce an Fc-antigen fusion protein. The Fc-antigen fusion proteins bind Fc receptors on the surface of antigen presenting cells, thereby targeting the antigen to the antigen presenting cells in the mammal. In addition, disclosed is a family of adjuvants, for example, an Fc-adjuvant fusion protein, for use in combination with the Fc-antigen fusion proteins to enhance or modulate a particular immune response against the preselected antigen.
Inventors:
Gillies, Stephen Dee.
Roh, Kin Min
Wesolowski, John S. Jr.
Roh, Kin Min
Wesolowski, John S. Jr.
Application Number:
JP2001511964A
Publication Date:
September 07, 2011
Filing Date:
July 21, 2000
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
A61K39/39; A61K38/16; A61K39/00; A61K39/12; A61K39/21; A61K39/385; A61P37/04; C07K14/16; C07K14/475; C07K14/52; C07K14/535; C07K14/705; C07K19/00; C12N15/62; G01N33/53
Domestic Patent References:
| JPH10506265A | 1998-06-23 | |||
| JPH04506663A | 1992-11-19 |
Foreign References:
| WO1997028816A1 | 1997-08-14 |
Attorney, Agent or Firm:
Koichi Tsujii
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Gen Tashiro
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Gen Tashiro