Title:
破骨細胞活性を阻害する方法
Document Type and Number:
Japanese Patent JP4790179
Kind Code:
B2
Abstract:
Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. According to the methods, an amount of a TRANCE/RANK inhibitor effective to inhibit osteoclastogenesis is administered to the patient. Pharmaceutical compositions which comprise TRANCE/RANK inhibitor in an amount effective to inhibit osteoclastogenesis. Methods of modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems in an individual are disclosed. The methods comprise the step of administering to the individual an amount of a TRANCE/RANK inhibitor effective to modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems.
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Inventors:
Ramachandran Murari
Mark eye green
Masahiko Kinosaki
Mark eye green
Masahiko Kinosaki
Application Number:
JP2001513407A
Publication Date:
October 12, 2011
Filing Date:
July 28, 2000
Export Citation:
Assignee:
The Trustees of the University of Pennsylvania
International Classes:
A61K38/00; A61K45/00; A61K31/00; A61K31/03; A61K31/235; A61K31/565; A61K31/585; A61K38/17; A61P1/02; A61P19/00; A61P19/02; A61P19/10; A61P29/00; A61P43/00; C07K5/103; C07K5/107; C07K5/113; C07K7/00; C07K14/705
Foreign References:
| WO1998028426A2 | 1998-07-02 |
Attorney, Agent or Firm:
Masatake Shiga
Tadashi Takahashi
Takashi Watanabe
Masakazu Aoyama
Suzuki Mitsuyoshi
Kazuya Nishi
Yasuhiko Murayama
Shinya Mitsuhiro
Tadashi Takahashi
Takashi Watanabe
Masakazu Aoyama
Suzuki Mitsuyoshi
Kazuya Nishi
Yasuhiko Murayama
Shinya Mitsuhiro