Title:
HSP70発現を増加するためのビス(チオ‐ヒドラジドアミド)
Document Type and Number:
Japanese Patent JP5204489
Kind Code:
B2
Abstract:
A method of treating a Hsp70-responsive disorder in a subject includes administering to the subject an effective amount of a compound represented by Structural Formula I, or a pharmaceutically acceptable salt or solvate thereof. Y is a covalent bond or an optionally substituted straight chained hydrocarbyl group, or, Y, taken together with both >C═Z groups to which it is bonded, is an optionally substituted aromatic group. R1-R4 are independently —H, an optionally substituted aliphatic group, an optionally substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. R7-R8 are independently —H, an optionally substituted aliphatic group, or an optionally substituted aryl group. Z is O or S.
More Like This:
Inventors:
Birthday, james
Application Number:
JP2007543254A
Publication Date:
June 05, 2013
Filing Date:
November 17, 2005
Export Citation:
Assignee:
Synta Pharmaceuticals Corp.
International Classes:
A61K31/165; A61P9/10; A61P21/04; A61P25/00; A61P25/02; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P27/06; A61P29/00; A61P31/04; A61P37/02; A61P43/00
Domestic Patent References:
| JP2004534846A | ||||
| JP2004534848A | ||||
| JP2005518366A |
Foreign References:
| WO2003047524A1 |
Attorney, Agent or Firm:
Yoshinori Hosoda