Title:
パントプラゾールナトリウムの製造方法
Document Type and Number:
Japanese Patent JP5355893
Kind Code:
B2
Abstract:
A one-pot process for the preparation of pantoprazole sodium by reacting 2-chloro methyl 3,4-dimethoxy pyridine hydrochloride with 2-mercapto-5-difluoromethoxy benzimidazole in an organic solvent system in presence of a phase transfer catalyst and further treating with aqueous sodium hypohalite solution comprising sodium hydroxide to obtain pantoprazole sodium in high yield and purity. The process for conversion of pantoprazole sodium to pantoprazole sodium sesquihydrate and also pantoprazole sodium monohydrate are also disclosed herein.
Inventors:
Rajendra Narayan Rao Cancan
Pathiel Srinivas
Pathiel Srinivas
Application Number:
JP2007546186A
Publication Date:
November 27, 2013
Filing Date:
December 15, 2005
Export Citation:
Assignee:
Shipra Limited
International Classes:
C07D401/12; A61K31/4439; A61P1/04; C07B61/00
Domestic Patent References:
| JP61022079A | ||||
| JP2004524303A | ||||
| JP2000502101A |
Foreign References:
| WO2004056804A1 | ||||
| WO2004035565A1 | ||||
| WO2001004109A1 | ||||
| WO1998009962A1 | ||||
| WO2004063188A1 |
Other References:
KOHL,B. et al.,(H+, K+)-ATPase inhibiting 2-[(2-pyridylmethyl)sulfinyl]benzimidazoles. 4. A novel series of dimethoxypyridyl-substituted inhibitors with enhanced selectivity. The selection of pantoprazole as a clinical candidate,Journal of Medicinal Chemistry ,1992年,Vol.35, No.6,p.1049-1057
社団法人 日本化学会編,標準化学用語辞典,丸善株式会社,1991年,p.683[ワンポット反応]
JAYACHANDRAN,J.P. et al.,Synthesis and spectral characterization of 2-mercaptobenzimidazole derivatives using a new active phase transfer reagent,Synthetic Communications,1999年,Vol.29, No.23,p.4087-4099
社団法人 日本化学会編,標準化学用語辞典,丸善株式会社,1991年,p.683[ワンポット反応]
JAYACHANDRAN,J.P. et al.,Synthesis and spectral characterization of 2-mercaptobenzimidazole derivatives using a new active phase transfer reagent,Synthetic Communications,1999年,Vol.29, No.23,p.4087-4099
Attorney, Agent or Firm:
Toru Ishikawa