ＩＬ−６Ｒ関連疾患及び障害の治療のためのＩＬ−６Ｒに指向性を有する改善されたアミノ酸配列及びこれを含むポリペプチド

Japanese Patent JP5647222

B2

The present invention relates to amino acid sequences that are directed against/and or that can specifically bind Interleukin-6 Receptor (IL-6R) with improved affinity and/or avidity, and/or that have an improved efficacy and/or potency, and which are capable of (partially, or preferably totally) blocking the IL-6/IL-6R interaction and/or inhibit signalization through IL-6, IL-6R and/or the IL-6/IL-6R complex. The invention further relates to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides, to methods for preparing such amino acid sequences and polypeptides, to host cells expressing or capable of expressing such amino acid sequences or polypeptides, to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells, and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.

バイラーナエール，エルス，アンナアリス
フェルフェルケン，セドリック ジョセフ ネオテレ
コルクマン，ヨースト アレクサンドル
ファン ロイ，マールテン

JP2012504035A

December 24, 2014

April 12, 2010

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アブリンクス エン．ヴェー．

C12N15/09; A61K38/00; A61K39/395; A61K48/00; A61P7/00; A61P13/12; A61P17/06; A61P19/08; A61P19/10; A61P29/00; A61P31/04; A61P35/00; A61P43/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12P21/08

Patent business corporation Tsukuni
Hajime Tsukuni
Ito 佐保子
Toshio Miyake
Akio Shibata
Yasuhiro Kokuni
Yoko Tanaka
Yoshinori Ubukawa
Satoshi Tanaka

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