Title:
タウオパチー治療用ワクチン
Document Type and Number:
Japanese Patent JP5697044
Kind Code:
B2
Abstract:
This invention relates to a vaccine for preventing or treating tautopathy, comprising a vector, as an active ingredient, comprising a nucleic acid encoding a mutant tau protein linked to a secretion signal sequence, wherein the vaccine is capable of inducing an antibody against an (optionally phospholylated) tau protein in a subject in a more sustained manner compared with a case where the mutant tau protein is administered directly.
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Inventors:
Haruhisa Inoue
Kei Takeuchi
Ryosuke Takahashi
Masato Higuchi
Season
Tetsuya Suhara
Kei Takeuchi
Ryosuke Takahashi
Masato Higuchi
Season
Tetsuya Suhara
Application Number:
JP2011549046A
Publication Date:
April 08, 2015
Filing Date:
January 11, 2011
Export Citation:
Assignee:
Kyoto University
National Institute of Radiological Sciences
National Institute of Radiological Sciences
International Classes:
A61K39/00; A61K48/00; A61P25/28
Domestic Patent References:
| JP2008536476A | 2008-09-11 | |||
| JP2005021149A | 2005-01-27 |
Foreign References:
| US20080050383A1 | 2008-02-28 |
Other References:
JPN6015002017; Ｈｕｍａｎ Ｖａｃｃｉｎｅｓ Ｖｏｌ．５, 2009, ｐ．３７３-３８０
JPN6015002018; ＢＭＣ Ｎｅｕｒｏｓｃｉｅｎｃｅ Ｖｏｌ．９， Ｓｕｐｐｌ．２, 2008, Ｓ１０
JPN6015002018; ＢＭＣ Ｎｅｕｒｏｓｃｉｅｎｃｅ Ｖｏｌ．９， Ｓｕｐｐｌ．２, 2008, Ｓ１０
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Satoshi Fujita