Title:
スムースンドポリペプチドおよび使用方法
Document Type and Number:
Japanese Patent JP5739484
Kind Code:
B2
Abstract:
Disclosed is an isolated or purified polypeptide or peptidomimetic comprising an amino acid sequence of a portion of a Smoothened (SMO) protein, wherein the portion comprises an amino acid sequence of any of the intracellular loops of the SMO protein, a functional fragment thereof, or a functional variant of either the portion or the functional fragment, wherein the functional fragment comprises at least 7 contiguous amino acids of the intracellular loops, and wherein the functional fragment or functional variant inhibits proliferation of a diseased cell, or a fatty acid derivative thereof. Related conjugates, nucleic acids, recombinant expression vectors, host cells, and pharmaceutical compositions are further provided. Methods of inhibiting proliferation of a diseased cell, treating or preventing cancer, treating a neoplasm or psoriasis, and inhibiting the expression of genes involved in the Hedgehog signaling pathway, thereby inhibiting the Hedgehog signaling pathway, are furthermore provided by the invention.
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Inventors:
Talasova, Nadia
Dean, Michael
Law, Hong
Dean, Michael
Law, Hong
Application Number:
JP2013150706A
Publication Date:
June 24, 2015
Filing Date:
July 19, 2013
Export Citation:
Assignee:
THE UNITED STATES OF AMERICA
International Classes:
C12N15/09; A61K38/00; A61K48/00; A61P35/00; C07K14/705
Domestic Patent References:
| JP2003530875A | ||||
| JP5399255B2 | ||||
| JP2008519039A |
Foreign References:
| WO2004111636A1 | ||||
| WO1999001468A1 |
Other References:
Cancer Res.,Vol.65,No.12(2005)p.4975-4978
J.Med.Chem.,Vol.50(2007)p.4534-4538
J.Med.Chem.,Vol.50(2007)p.4534-4538
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki
Junzo Koike
Hirofumi Toma
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki
Junzo Koike
Hirofumi Toma