Title:
トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法
Document Type and Number:
Japanese Patent JP5756151
Kind Code:
B2
Abstract:
Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective treatment or prophylaxis for such diseases. Treatment methods, screening methods, as well as specific transthyretin stabilizing compounds are disclosed.
Inventors:
Kelly, Jeffrey, W.
Yoshiki Sekijima
Yoshiki Sekijima
Application Number:
JP2013170867A
Publication Date:
July 29, 2015
Filing Date:
August 21, 2013
Export Citation:
Assignee:
The Script Research Institute
International Classes:
A61K31/603; A61K31/03; A61K31/055; A61K31/192; A61P9/00; A61P25/00; A61P43/00; C07D263/57; C07K1/00; G01N33/50; G01N33/53; G01N33/567; G01N33/68; C07D263/56; A61K
Other References:
Bioorganic & Medicinal Chemistry,1999年,7,p.1339-1347
Br. J. clin. Pharmac.,1977年,4,p.31S-36S
Br. J. clin. Pharmac.,1977年,4,p.31S-36S
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita
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