Title:
置換縮合ピリミジン化合物
Document Type and Number:
Japanese Patent JP5765239
Kind Code:
B2
Abstract:
The present invention discloses substituted fused pyrimidine compounds of formula (I), their tautomers, polymorphs, stereoisomers, solvates, pharmaceutically acceptable salts, or pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by adenosine receptor (AR) activity; the compounds of the present invention are useful in the treatment, prevention or suppression of diseases and disorders that may be susceptible to improvement by antagonism of the adenosine receptor, such as asthma, chronic obstructive pulmonary disorder, angiogenesis, pulmonary fibrosis, emphysema, allergic diseases, inflammation, reperfusion injury, myocardial ischemia, atherosclerosis, hypertension, congestive heart failure, retinopathy, diabetes mellitus, obesity, inflammatory gastrointestinal tract disorders, and/or autoimmune diseases.
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Inventors:
Venkata Palais
Vidya Lambdas
Dinesh Balaucar
Sujay Basu
Smon Cowl
Yogesh Warman
Mina Patel
Annealed Panmund
Vidya Lambdas
Dinesh Balaucar
Sujay Basu
Smon Cowl
Yogesh Warman
Mina Patel
Annealed Panmund
Application Number:
JP2011553603A
Publication Date:
August 19, 2015
Filing Date:
March 12, 2010
Export Citation:
Assignee:
Advinus Therapeutics Limited
International Classes:
C07D473/06; C07D473/18; C07D473/30; C07D473/40
Domestic Patent References:
| JP5508647A | ||||
| JP2006515316A | ||||
| JP2004534828A | ||||
| JP2007509947A |
Foreign References:
| US3573309 | ||||
| GB683523B | ||||
| GB1073040B | ||||
| WO1999012546A1 | ||||
| WO2004014916A1 |
Other References:
Sharma, R. C.; Singh, P.; Ojha, T. N.; Tiwari, S.,A quantitative analysis of binding affinities of ligands active at adenosine receptors,Drug Design and Discovery,1994年,12(2),169-77
LAURIA A,DOCKING OF INDOLO-AND PYRROLO-PYRIMIDINES TO DNA. NEW DNA-INTERACTIVE POLYCYCLES 以下備考,ARKIVOC,2004年,V5,P263-271,FROM AMINO-INDOLES/PYRROLES AND BMMA
FU H,REGIOSPECIFIC SOLID-PHASE STRATEGY TO N7-SUBSTITUTED PURINES AND ITS APPLICATION 以下備考,JOURNAL OF COMBINATORIAL CHEMISTRY,2007年,V9 N5,P804-810,TO 8-AZAPURINES AND [I]-CONDENSED PURINES
BERGMANN F,INFLUENCE OF 8-SUBSTITUENTS ON THE OXIDATION OF HYPOXANTHINE AND 6-THIOXOPURINE 以下備考,BBA ENZYMOLOGY,NL,ELSEVIER,1977年 1月11日,V480 N1,P39-46,BY BOVINE MILK XANTHINE OXIDASE
RYABUKHIN S V,SYNTHESIS OF FUSED IMIDAZOLES AND BENZOTHIAZOLES FROM(HETERO)AROMATIC ORTHO-DIAMINES 以下備考,SYNTHESIS,2006年,N21,P3715-3726,OR ORTHO-AMINOTHIOPHENOL AND ALDEHYDES PROMOTED BY CHLOROTRIMETHYLSILANE
COOK A H,AZOLE SERIES XXX NEW SYNTHESES OF 2-AND-8-AMINOPURINES,JOURNAL OF THE CHEMICAL SOCIETY,英国,CHEMICAL SOCIETY,1950年 1月 1日,P1888-1891
COOK A H,AZOLE SERIES XIV A NEW SYNTHESIS OF PURINES,JOURNAL OF THE CHEMICAL SOCIETY,英国,CHEMICAL SOCIETY,1949年 1月 1日,P1071-1074
NEIMAN,REDUCTION OF QUATERNARY PTERDINES AND PURINES BY SODIUM BOROHYDRIDE,JOURNAL OF THE CHEMICAL SOCIETY SECTION C ORGANIC CHEMISTRY,英国,CHEMICAL SOCIETY,1970年 1月 1日,N1,P91-94
BERGMANN,ELECTROPHILIC AND NUCLEOPHILIC SUBSTITUTION REACTIONS OF 8-PYRIDYL-AND 8-(1-METHYLPYRIDINIO)-PURINES,JOURNAL OF THE CHEMICAL SOCIETY SECTION C ORGANIC CHEMISTRY,英国,CHEMICAL SOCIETY,1969年 1月 1日,V14,P1831-1845
Bergmann, F.; Tamir, I.; Neiman, Z.; Lichtenberg, D.,Nuclear magnetic resonance study of hindered rotation in 8-phenylpurines,Tetrahedron,1974年,30(17),3045-3051
PATANI G A,BIOISOSTERISM: A RATIONAL APPROACH IN DRUG DESIGN,CHEMICAL REVIEWS,米国,AMERICAN CHEMISTRY SOCIETY,1996年 1月 1日,V96 N8,P3147-3176
LAURIA A,DOCKING OF INDOLO-AND PYRROLO-PYRIMIDINES TO DNA. NEW DNA-INTERACTIVE POLYCYCLES 以下備考,ARKIVOC,2004年,V5,P263-271,FROM AMINO-INDOLES/PYRROLES AND BMMA
FU H,REGIOSPECIFIC SOLID-PHASE STRATEGY TO N7-SUBSTITUTED PURINES AND ITS APPLICATION 以下備考,JOURNAL OF COMBINATORIAL CHEMISTRY,2007年,V9 N5,P804-810,TO 8-AZAPURINES AND [I]-CONDENSED PURINES
BERGMANN F,INFLUENCE OF 8-SUBSTITUENTS ON THE OXIDATION OF HYPOXANTHINE AND 6-THIOXOPURINE 以下備考,BBA ENZYMOLOGY,NL,ELSEVIER,1977年 1月11日,V480 N1,P39-46,BY BOVINE MILK XANTHINE OXIDASE
RYABUKHIN S V,SYNTHESIS OF FUSED IMIDAZOLES AND BENZOTHIAZOLES FROM(HETERO)AROMATIC ORTHO-DIAMINES 以下備考,SYNTHESIS,2006年,N21,P3715-3726,OR ORTHO-AMINOTHIOPHENOL AND ALDEHYDES PROMOTED BY CHLOROTRIMETHYLSILANE
COOK A H,AZOLE SERIES XXX NEW SYNTHESES OF 2-AND-8-AMINOPURINES,JOURNAL OF THE CHEMICAL SOCIETY,英国,CHEMICAL SOCIETY,1950年 1月 1日,P1888-1891
COOK A H,AZOLE SERIES XIV A NEW SYNTHESIS OF PURINES,JOURNAL OF THE CHEMICAL SOCIETY,英国,CHEMICAL SOCIETY,1949年 1月 1日,P1071-1074
NEIMAN,REDUCTION OF QUATERNARY PTERDINES AND PURINES BY SODIUM BOROHYDRIDE,JOURNAL OF THE CHEMICAL SOCIETY SECTION C ORGANIC CHEMISTRY,英国,CHEMICAL SOCIETY,1970年 1月 1日,N1,P91-94
BERGMANN,ELECTROPHILIC AND NUCLEOPHILIC SUBSTITUTION REACTIONS OF 8-PYRIDYL-AND 8-(1-METHYLPYRIDINIO)-PURINES,JOURNAL OF THE CHEMICAL SOCIETY SECTION C ORGANIC CHEMISTRY,英国,CHEMICAL SOCIETY,1969年 1月 1日,V14,P1831-1845
Bergmann, F.; Tamir, I.; Neiman, Z.; Lichtenberg, D.,Nuclear magnetic resonance study of hindered rotation in 8-phenylpurines,Tetrahedron,1974年,30(17),3045-3051
PATANI G A,BIOISOSTERISM: A RATIONAL APPROACH IN DRUG DESIGN,CHEMICAL REVIEWS,米国,AMERICAN CHEMISTRY SOCIETY,1996年 1月 1日,V96 N8,P3147-3176
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe