Title:
ヒト抗ＴＳＨＲ抗体
Document Type and Number:
Japanese Patent JP5784504
Kind Code:
B2
Abstract:
According to one aspect there is provided An isolated human antibody molecule which binds to the TSHR and which reduces ligand-induced stimulation of the TSHR but has no effect on the TSHR constitutive activity wherein the isolated human antibody molecule has the characteristic of patient serum TSHR autoantibodies of inhibiting TSH and M22 binding to the TSHR.
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Inventors:
Reese Smith, Bernard
Jane Sanders
Farmmaniac, Jadwiga
Jane Sanders
Farmmaniac, Jadwiga
Application Number:
JP2011542893A
Publication Date:
September 24, 2015
Filing Date:
December 23, 2009
Export Citation:
Assignee:
RS Limited
International Classes:
C12N15/09; A61K39/395; A61P5/14; A61P35/00; A61P43/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; G01N33/53
Domestic Patent References:
| JP2003125780A | ||||
| JP2000236882A | ||||
| JP2000308482A |
Foreign References:
| WO2007057778A1 | ||||
| WO2006016121A1 | ||||
| WO2003018632A1 | ||||
| WO2008099185A1 |
Other References:
SANDERS, J. et al.,"Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody.",THYROID,2007年 5月,Vol.17, No.5,P.395-410
REES SMITH, B. et al.,"TSH RECEPTOR - AUTOANTIBODY INTERACTIONS.",HORMONE AND METABOLIC RESEARCH,2009年 6月,Vol.41, No.6,P.448-455
MORGENTHALER, N.G. et al.,"STIMULATING AND BLOCKING THYROID-STIMULATING HORMONE (TSH) RECEPTOR AUTOANTIBODIES FROM PATIENTS WITH GRAVES' DISEASE AND AUTOIMMUNE HYPOTHYROIDISM HAVE VERY SIMILAR CONCENTRATION.",JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2007年 3月,Vol.92, No.3,P.1058-1065
VALENTE, W.A. et al.,"MONOCLONAL ANTIBODIES TO THE THYROTROPIN RECEPTOR: STIMULATING AND BLOCKING ANTIBODIES DERIVED FROM THE LYMPHOCYTES OF PATIENTS WITH GRAVES DISEASE.",PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,1982年11月 1日,Vol.79, No.21,P.6680-6684
KOHN, L.D. et al.,"CHARACTERIZATION OF MONOCLONAL THYROID-STIMULATING AND THYROTROPIN BINDING-INHIBITING AUTOANTIBODIES FROM A HASHIMOTO'S PATIENT WHOSE CHILDREN HAD INTRAUTERINE.",JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM,1997年12月 1日,Vol.82, No.12,P.3998-4009
SMITH, B.R. et al.,"TSH RECEPTOR ANTIBODIES.",THYROID,2007年10月 1日,Vol.17, No.10,P.923-938
REES SMITH, B. et al.,"TSH RECEPTOR - AUTOANTIBODY INTERACTIONS.",HORMONE AND METABOLIC RESEARCH,2009年 6月,Vol.41, No.6,P.448-455
MORGENTHALER, N.G. et al.,"STIMULATING AND BLOCKING THYROID-STIMULATING HORMONE (TSH) RECEPTOR AUTOANTIBODIES FROM PATIENTS WITH GRAVES' DISEASE AND AUTOIMMUNE HYPOTHYROIDISM HAVE VERY SIMILAR CONCENTRATION.",JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2007年 3月,Vol.92, No.3,P.1058-1065
VALENTE, W.A. et al.,"MONOCLONAL ANTIBODIES TO THE THYROTROPIN RECEPTOR: STIMULATING AND BLOCKING ANTIBODIES DERIVED FROM THE LYMPHOCYTES OF PATIENTS WITH GRAVES DISEASE.",PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,1982年11月 1日,Vol.79, No.21,P.6680-6684
KOHN, L.D. et al.,"CHARACTERIZATION OF MONOCLONAL THYROID-STIMULATING AND THYROTROPIN BINDING-INHIBITING AUTOANTIBODIES FROM A HASHIMOTO'S PATIENT WHOSE CHILDREN HAD INTRAUTERINE.",JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM,1997年12月 1日,Vol.82, No.12,P.3998-4009
SMITH, B.R. et al.,"TSH RECEPTOR ANTIBODIES.",THYROID,2007年10月 1日,Vol.17, No.10,P.923-938
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi
Hidemi Matsukura
Shinichi Sanuki
Takeshi Niwa
Hidemi Matsukura
Shinichi Sanuki
Takeshi Niwa