Title:
生理活性物質等の生体内安定性向上のためのペプチド及び生体内安定性が向上した生理活性物質
Document Type and Number:
Japanese Patent JP5827218
Kind Code:
B2
Abstract:
The present invention aims at providing a peptide fragment capable of improving biostability of a bioactive substance while maintaining the activity of the bioactive substance, and a bioactive substance to which the peptide fragment is added. The present invention relates to a partial peptide of a GA module having 5 to 25 amino acids, including a partial sequence of a GA module (SEQ ID NO: 1) and the amino acid sequence Ile-Asp-Glu-Ile-Leu (SEQ ID NO: 2), and a bioactive complex in which the partial peptide of the GA module is bound to a bioactive substance. The bioactive substance includes GLP-1, GLP-2, GIP, VIP, somatostatin, amylin, ghrelin, derivatives thereof, and the like.
Inventors:
Masayuki Okamoto
Takashi Okamoto
Shigemori Tomohiro
Takayo Murase
Atsushi Miyaji
Mitsuaki Takeuchi
Miyuki Tamura
Hiroshi Kinoshita
Takashi Okamoto
Shigemori Tomohiro
Takayo Murase
Atsushi Miyaji
Mitsuaki Takeuchi
Miyuki Tamura
Hiroshi Kinoshita
Application Number:
JP2012512918A
Publication Date:
December 02, 2015
Filing Date:
April 28, 2011
Export Citation:
Assignee:
Sanwa Chemical Laboratory Co., Ltd.
International Classes:
C07K7/04; C07K14/315
Foreign References:
| WO2009016043A2 | 2009-02-05 | |||
| WO2008005527A2 | 2008-01-10 |
Other References:
JPN6015020256; ＰＬｏＳ Ｐａｔｈｏｇｅｎｓ Ｖｏｌ．３，Ｎｏ．１０, 2007, ｅ１４４
JPN6015020255; Ｃｌｉｎｉｃａｌ ａｎｄ Ｄｉａｇｎｏｓｔｉｃ Ｌａｂｏｒａｔｏｒｙ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．１０，Ｎｏ．１, 2003, ｐ．１２５-１３２
JPN6015020255; Ｃｌｉｎｉｃａｌ ａｎｄ Ｄｉａｇｎｏｓｔｉｃ Ｌａｂｏｒａｔｏｒｙ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．１０，Ｎｏ．１, 2003, ｐ．１２５-１３２