Title:
チオフィリック固相およびチオオキソヌクレオチドを含むオリゴヌクレオチドの間のコンジュゲート
Document Type and Number:
Japanese Patent JP5845270
Kind Code:
B2
Abstract:
An oligonucleotide-solid phase conjugate, wherein the solid phase is thiophilic and the oligonucleotide comprises at least one thiooxonucleobase according to Formula I, wherein X is CH or N, R1 is H or NH2, --- indicates a covalent bond, and said oligonucleotide is bound to said solid phase via the sulfur atom of said thiooxonucleotide. Also disclosed are methods for producing such conjugate as well as various uses for such oligonucleotide metal conjugate.
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Inventors:
Grapes, zimone
Dean, Pean
Heindle, Dieter
Nichtol, Alphonse
Zela, frank
Dean, Pean
Heindle, Dieter
Nichtol, Alphonse
Zela, frank
Application Number:
JP2013534203A
Publication Date:
January 20, 2016
Filing Date:
October 21, 2011
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C12N15/09; C12Q1/68
Domestic Patent References:
| JP2002000299A |
Other References:
Biochem. Biophys. Res. Commun., (2008), 366, [2], p.420-425
Nucleic Acids Res., (1999), 27, [20], p.4034-4039
Nucleic Acids Res., (1999), 27, [20], p.4034-4039
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Osamu Hoshino
Osamu Yamamoto
Yasushi Kobayashi
Osamu Hoshino
Osamu Yamamoto