Title:
遺伝子改変されたマウスおよび移植方法
Document Type and Number:
Japanese Patent JP6408497
Kind Code:
B2
Abstract:
A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mll2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modelled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic dells is described, e.g., a myeloid leukemia or a myeloproliferative neoplasia.
Inventors:
Stevens Sean
Murphy Andrew Jay.
Flavel richard
Ainon Elizabeth
Galan George
Willinger Tim
Manz Marcus
Rhombo Anthony
Janko Pourras George Dee.
Murphy Andrew Jay.
Flavel richard
Ainon Elizabeth
Galan George
Willinger Tim
Manz Marcus
Rhombo Anthony
Janko Pourras George Dee.
Application Number:
JP2016000323A
Publication Date:
October 17, 2018
Filing Date:
January 05, 2016
Export Citation:
Assignee:
REGENERON PHARMACEUTICALS, INC.
Hyeres University
Institute for Research in Biomedicine (IRB)
Hyeres University
Institute for Research in Biomedicine (IRB)
International Classes:
C12N15/09; A01K67/027; C12Q1/02
Domestic Patent References:
| JP5874881B2 | ||||
| JP2002501375A | ||||
| JP2005537805A | ||||
| JP2013506433A |
Foreign References:
| WO2008010100A1 | ||||
| WO2008069659A1 | ||||
| WO2009034328A1 | ||||
| WO2004005496A1 |
Other References:
Nat. Immunol.,2009年10月 1日,Vol.10, No.10,p.1039-1042
J. Immunol.,2006年,Vol.176,p.2053-2058
J. Interferon Cytokine Res.,1999年,Vol.19,p.533-541
Cell Host & Microbe,2009年 6月,Vol.6,p.5-9
Nippon Rinsho,2008年,Vol.66, Suppl 6,p.95-99
J. Immunol.,2006年,Vol.176,p.2053-2058
J. Interferon Cytokine Res.,1999年,Vol.19,p.533-541
Cell Host & Microbe,2009年 6月,Vol.6,p.5-9
Nippon Rinsho,2008年,Vol.66, Suppl 6,p.95-99
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto