Title:
窒素捕集薬の治療監視の方法
Document Type and Number:
Japanese Patent JP6425746
Kind Code:
B2
Abstract:
The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods that utilize this technique to adjust the dosage of a nitrogen scavenging drug, determine whether to administer a nitrogen scavenging drug, and treat nitrogen retention disorders.
Inventors:
Sherschmitt, Bruce
Mokatalani, Masado
Mokatalani, Masado
Application Number:
JP2017000550A
Publication Date:
November 21, 2018
Filing Date:
January 05, 2017
Export Citation:
Assignee:
Horizon Therapeutics, LRC
International Classes:
G01N33/50; A61K31/192; A61K31/216; A61P1/16; A61P3/00; A61P25/00; A61P39/02; A61P43/00
Domestic Patent References:
| JP2008521784A |
Foreign References:
| US20100008859 |
Other References:
ENNS GM et al.,Survival afer Treatment with Phenylacetate and Benzoate for Urea-Cycle Disorders,THE NEW ENGLAND JOURNAL OF MEDICINE,Massachusetts Medical Society,2007年 5月31日,Vol.356 / No.22,pp.2282-2292
Lichter-Konecki U et al.,Ammonia control in children with urea cycle disorders (UCDs); Phase 2 comparison of sodium phenylbutyrate and glycerol phenylbutyrate,Molecular Genetics and Metabolism,Elsevier Inc.,2011年 5月 5日,Vol.103,pp.323-329
Lichter-Konecki U et al.,Ammonia control in children with urea cycle disorders (UCDs); Phase 2 comparison of sodium phenylbutyrate and glycerol phenylbutyrate,Molecular Genetics and Metabolism,Elsevier Inc.,2011年 5月 5日,Vol.103,pp.323-329
Attorney, Agent or Firm:
Tadashige Ito
Tadahiko Ito
Shinsuke Onuki
Tadahiko Ito
Shinsuke Onuki