Title:
糖尿病の予防及び治療用の置換芳香族化合物及び医薬組成物
Document Type and Number:
Japanese Patent JP6676629
Kind Code:
B2
Abstract:
The present invention concerns the use of compounds for preventing and/or treating diabetes, for modulating glucose, insulin, and/or triglyceride levels; for reducing blood glucose level; for maintaining or increasing insulin level; for increasing insulin secretion; increasing insulin sensitivity; or decreasing insulin resistance in a subject. These novel uses have been found for compounds represented by Formula I and pharmaceutically acceptable salts. wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R1 is H, F or OH; R2 is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH or CH2Ph; R4 is H, F or OH; Q is 1) (CH2)mC(O)OH wherein m is 1 or 2, 2) CH(CH3)C(O)OH, 3) C(CH3)2 C(O)OH, 4) CH(F)- C(O)OH, 5) CF2- C(O)OH, or 6) C(O)- C(O)OH.
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Inventors:
Lynn Ganion
Bridget glue
Bridget glue
Application Number:
JP2017518943A
Publication Date:
April 08, 2020
Filing Date:
October 08, 2015
Export Citation:
Assignee:
PROMETIC PHARMA SMT LIMITED
International Classes:
A61K31/192; A61K31/155; A61K31/426; A61P3/10; A61P43/00
Domestic Patent References:
| JP2012072136A |
Foreign References:
| WO2014138906A1 | ||||
| CA2788326A1 |
Attorney, Agent or Firm:
Takuji Yamada
Aoyama Aoi
Michiko Matsutani
Yasushi Ochiai
Aoyama Aoi
Michiko Matsutani
Yasushi Ochiai