Title:
樹状細胞組成物
Document Type and Number:
Japanese Patent JP6697562
Kind Code:
B2
Abstract:
The present invention contemplates methods for the generation of human antigen-specific T lymphocytes. The methods employ MHC class-II targeting signals fused to an antigen or fragment thereof to obtain MHC class presentation of RNA coded proteins. Accordingly, the present invention concerns expression vectors comprising MHC class-II targeting signal and at least one antigen or fragment thereof and its use for the in vitro generation of antigen-specific T lymphocytes. T cell clones and T cell receptors (TCRs) specific for tumor antigens or viral antigens are also described.
Inventors:
Milosevic, Slavolyubu
Ellinger, Christian
Weener, Carina
Schondel, Dolores
Ellinger, Christian
Weener, Carina
Schondel, Dolores
Application Number:
JP2018533086A
Publication Date:
May 20, 2020
Filing Date:
December 22, 2016
Export Citation:
Assignee:
Medigene Immunotherapy GAME BAHA
International Classes:
C12N15/85; A61K35/15; A61K39/00; A61P17/00; A61P35/00; A61P37/04; C12N5/0784; C12N5/10
Other References:
Bonehill A. et al.,Messenger RNA-electroporated dendritic cells presenting MAGE-A3 simultaneously in HLA class I and class II molecules.,J Immunol.,2004年,172(11),6649-6657
Wehner C.,Induktion Tumorantigen-spezifischer CD8+ T-Lymphozyten in vitro und in vivo,博士論文,2013年 7月 1日,
RecName: Full=Lysosome-associated membrane glycoprotein 1,Uniprot AC:P11279 (LAMP1_HUMAN),2015年12月 9日,
RecName: Full=Lysosome-associated membrane glycoprotein 3; (LAMP-3),Uniprot AC:Q9UQV4 (LAMP3_HUMAN),2015年11月11日,
Spranger S. et al.,Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075,J Immunol.,2010年,185(1),738-747
Wehner C.,Induktion Tumorantigen-spezifischer CD8+ T-Lymphozyten in vitro und in vivo,博士論文,2013年 7月 1日,
RecName: Full=Lysosome-associated membrane glycoprotein 1,Uniprot AC:P11279 (LAMP1_HUMAN),2015年12月 9日,
RecName: Full=Lysosome-associated membrane glycoprotein 3; (LAMP-3),Uniprot AC:Q9UQV4 (LAMP3_HUMAN),2015年11月11日,
Spranger S. et al.,Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075,J Immunol.,2010年,185(1),738-747
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Kyoei Sugiyama
Yasuhito Suzuki
Norio Omori
Kyoei Sugiyama
Yasuhito Suzuki