Title:
ＦＶＩＩＩ：Ｃ／ＦＶＩＩＩ：Ａｇの改良された比を有する第ＶＩＩＩ因子を製造するための方法
Document Type and Number:
Japanese Patent JP6778111
Kind Code:
B2
Abstract:
A process for manufacturing of a Factor VIII product having a ratio of FVIII:C/FVIII:Ag of at least 0.7 in the Factor VIII product by using chromatography wherein at least one chromatographic step is performed by means of employing; An affinity chromatography resin having an affinity for specifically binding of Factor VIII which is effected by an affinity ligand which is immobilised on the affinity chromatography resin, said affinity ligand is a 13 kD yeast derived Fab antibody fragment directed to the Factor VIII molecule. An anionic chromatography resin. A size exclusion resin. A Factor VIII product obtainable according to the process with a monomer content of >98% for treatment of haemophilia and avoiding formation of inhibitors.
Inventors:
Vinge, Stephan
Dadaian, Marina
Johansson, Erica
Fuchs, Bilte
Dadaian, Marina
Johansson, Erica
Fuchs, Bilte
Application Number:
JP2016547543A
Publication Date:
October 28, 2020
Filing Date:
January 20, 2015
Export Citation:
Assignee:
Octapharma Age
International Classes:
C07K1/22; A61K38/37; A61P7/04; C07K1/16; C07K1/18; C07K14/755
Domestic Patent References:
| JP2011525523A |
Attorney, Agent or Firm:
Atsushi Nakajima
Kato Kazunori
Kato Kazunori