ヒトプログラム死リガンド２（ＰＤ−Ｌ２）に結合する抗体およびその用途

Title:

ヒトプログラム死リガンド２（ＰＤ−Ｌ２）に結合する抗体およびその用途

Document Type and Number:

Japanese Patent JP6949009

Kind Code:

B2

Abstract:

The present disclosure provides antibodies and antigen binding fragments thereof including, but not limited to, monoclonal antibodies that specifically bind to human programmed death ligand 2 (PD-L2). The invention further provides nucleic acids encoding the antibodies and antigen binding fragments of the invention and host cells transformed therewith. The antibodies and antigen binding proteins of the invention are useful in methods for the immunohistochemical detection of human PD-L2 expression in tissue samples.

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Inventors:

Jerry, Jennifer H
Lian, Linda
Bigler, Michael Eric
Gibson, Christopher John

Application Number:

JP2018514829A

Publication Date:

October 13, 2021

Filing Date:

September 20, 2016

Export Citation:

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Assignee:

Merck Sharp & Dohme Corp.

International Classes:

C12N15/13; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; G01N33/53; G01N33/574

Other References:

Clin. Cancer Res., 2014, Vol.20, pp.5064-5074
Am J Surg Pathol., 2014, Vol.38, pp.1715-1723

Attorney, Agent or Firm:

Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama

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