Title:
アルツハイマー病の病原性因子としてのグラニンの同定、およびグラニン凝集を阻害し、アルツハイマー病を治療するための組成物及び方法
Document Type and Number:
Japanese Patent JP7432244
Kind Code:
B2
Abstract:
Compositions for inhibiting the aggregation of a granin from a non-toxic low molecular weight form to a toxic high molecular weight aggregated form and/or dissociating a high molecular weight aggregated form to a low molecular weight form are provided. Such a composition typically includes one or more active compounds or agents, which may also be referred to herein as disaggregation compounds. Using the compounds and compositions described herein, methods of i) modulating, inhibiting or preventing the interaction of granins with metal ions, ii) modulating, inhibiting, preventing the aggregation of granins or dissociating aggregated granins, iii) reducing or inhibiting cell toxicity, iv) treating or preventing dementia or Alzheimer's disease, and v) preventing or treating Parkinson's and/or Huntington's diseases are also provided.
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Inventors:
Yoo, Seung Hyun
Application Number:
JP2020555225A
Publication Date:
February 16, 2024
Filing Date:
April 12, 2019
Export Citation:
Assignee:
Yoo, Seung Hyun
International Classes:
A61K31/05; A61K31/353; A61K31/517; A61K31/7076; A61P25/28
Domestic Patent References:
| JP2003532634A |
Foreign References:
| WO2017031300A1 | ||||
| US20080026086 | ||||
| US20090163580 | ||||
| US20110111014 | ||||
| KR1020150040618A |
Other References:
CNA & Neurological Disorders:Drug Targets、2017年、Vol.16、No.4、p.387-397
Attorney, Agent or Firm:
Hitoshi Shimbo