Title:
【発明の名称】CRF類似体
Document Type and Number:
Japanese Patent JPH03501858
Kind Code:
A
Abstract:
Analogs of CRF, which are based upon hCRF, oCRF, sauvagine and alpha-helical CRF, are disclosed that can be administered to achieve a substantial elevation of ACTH, beta -endorphin, beta -lipotropin, other products of the pro-opiomelanocortin gene and corticosterone levels and/or an increase in blood pressure over an extended period of time. One analog which has been found to be particularly potent is: H-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu- Val-Leu-D- Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Le u-Leu-Asp- Ile-Ala-NH2. In the analogs, one or more of the first six N-terminal residues may be deleted and/or the N-terminal alpha-amino group may be acylated by an acylating agent containing up to 7 carbon atoms. A number of other substitutions may also be made throughout the chain. These analogs or pharmaceutically or veterinarily acceptable salts thereof, dispersed in a pharmaceutically or veterinarily acceptable liquid or solid carrier, can be administered to mammals, including humans. These analogs may also be used as stimulants to elevate mood and improve memory and learning, as well as diagnostically.
Inventors:
Revere, Gene Edoard Frederick
Veil, Wiley Walker Jr.
Veil, Wiley Walker Jr.
Application Number:
JP51046989A
Publication Date:
April 25, 1991
Filing Date:
September 28, 1989
Export Citation:
Assignee:
The Salk Institute for Biological Studies
International Classes:
A61P1/00; A61P9/12; A61K38/04; A61P25/00; A61P25/02; C07K14/575; A61K38/00; (IPC1-7): A61K37/43; C07K7/10; C07K99/00
Attorney, Agent or Firm:
Kyozo Yuasa (4 outside)