【発明の名称】置換二環式化合物のN‐イミダゾリル及びN‐イミダゾリルメチル誘導体

Title:

【発明の名称】置換二環式化合物のN‐イミダゾリル及びN‐イミダゾリルメチル誘導体

Document Type and Number:

Japanese Patent JPH03501859

Kind Code:

A

Abstract:

The present invention relates to new N-imidazolyl and N-imidazolylmethyl derivatives of bicyclic compounds having the general formula (I) Wherein A is a @CR3 or @CHR3 group, in which R3 is hydrogen or C1-C6 alkyl, or a @C=CR4R5 group, in which each of R4 and R5 independently is hydrogen or C1-C5 alkyl; Z is -CH2-, -O- or -S-; n is zero or 1; each of R and R1 is independently hydrogen or C1-C6 alkyl; R2 is -COCH2OH, -CH2OR min , -COOR min , -CONR min R sec or -CH=CH-COOR min , in which each of R min and R sec independently is hydrogen or C1-C6 alkyl, and the pharmaceutically acceptable salts thereof; and wherein: a) when n is zero, then Z is -CH2- or -O-; whereas when n is one, then Z is -CH2-, -O- or -S-; b) when A is @CR3 or @CHR3 in which R3 is hydrogen, then n is one; and c) when , at the same time,A is @CHR3 in which R3 is hydrogen, Z is -CH2-, n is one and R2 is -COOR min wherein R min is as defined above, then at least one of R and R1 is other than hydrogen. which are useful in the treatment of diseases related to an enhancement of TxA2 synthesis.

More Like This:

JPS6018655	[Title of the Invention] Azo Rilu- (1)-methane and those salt
JPS54125667	TRIAZOLE OR IMIDAZOLE DERIVATIVE*ITS MANUFACTURE AND HERBICIDAL COMPOSITION CONTAINING SAID DERIVATIVE
WO/1992/010481	PROCESS FOR PRODUCING FLUID IMIDAZOLINIUM TENSIDES BY QUATERNARY TRANSFORMATION OF 1-HYDROXYETHYL-2-ALKYLIMIDAZOLINES

Inventors:

Carganico, The Hermano
Kotsui, Paolo
Pitlan, Antonio
Salvati, Patricia
Fuertay, Kosrad

Application Number:

JP51059789A

Publication Date:

April 25, 1991

Filing Date:

October 03, 1989

Export Citation:

Click for automatic bibliography generation Help

Assignee:

Faria Talia Carlo Erba Etsuse Elle Elle

International Classes:

C07D233/60; A61K31/415; A61P3/06; A61P3/08; A61P7/02; A61P9/08; A61P13/02; A61P15/00; A61P25/04; A61P43/00; C07D233/56; C07D405/04; C07D405/06; C07D409/04; C07D409/06; C07D521/00; (IPC1-7): A61K31/415; C07D233/60; C07D405/04; C07D405/06; C07D409/04; C07D409/06

Attorney, Agent or Firm:

Yoshio Kawaguchi (2 outside)

Previous Patent: JPH03501858

Next Patent: PIEZOELECTRIC/ELECTROSTRICTION TYPE ELEMENT, AND ITS MANUFACTURE