Document Type and Number:
Japanese Patent JPH0545595
Kind Code:
B2
Abstract:
A series of 1,4-dihydropyrid-5-yl cyclic imidate esters have been prepared possessing the general formula wherein R and R1 are independently selected from hydrogen, lower alkyl or alkoxyalkyl groups; R2 is lower alkyl, aryl, or hetaryl; R3 is cycloalkyl, aryl or hetaryl, generally with electron-withdrawing substituents; R4 is lower alkyl, alkoxyalkyl, aminoalkyl, haloalkyl, or dialkylaminoalkyl; R5 is lower alkyl or aryl; m is 0 or 1; and n is 0, 1, or 2. Compounds of this series demonstrate blockage of calcium ion flux in tissue preparations in vitro and vasodilation in animal testing in vivo.
Inventors:
GURAHAMU ESU HOINDEKUSUTAA
DEIBISU ERU TENPURU JUNIA
DEIBISU ERU TENPURU JUNIA
Application Number:
JP7417983A
Publication Date:
July 09, 1993
Filing Date:
April 28, 1983
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO
International Classes:
C07C69/66; A61K31/395; A61K31/435; A61K31/44; A61K31/445; A61K31/535; A61K31/5377; A61P3/00; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P43/00; C07C69/738; C07C205/56; C07D209/18; C07D211/82; C07D211/90; C07D213/55; C07D263/08; C07D263/10; C07D263/28; C07D267/06; C07D269/02; C07D273/01; C07D307/16; C07D307/54; C07D333/24; C07D413/04; C07D413/06; C07D413/14; C07D263/14; C07D265/08; (IPC1-7): C07D413/04; C07D413/14