Title:
【発明の名称】単球および/またはマクロファージによるインターロイキン―1または腫瘍壊死因子生成の抑制
Document Type and Number:
Japanese Patent JPH05503919
Kind Code:
A
Abstract:
A method of inhibiting the production of interleukin-1 by monocytes and/or macrophages in a human in need thereof which comprises administering to such a human an effective, interleukin-1 production inhibiting amount of a diaryl-substituted imidazole fused to a second heterocyclic ring containing a nitrogen bridgehead atom wherein said second ring may also contain sulfur, oxygen or an additional nitrogen atom, and may contain additional unsaturation. This invention relates to a method of inhibiting the production of Tumor Necrosis Factor (TNF) by monocytes or macrophages in a human in need thereof which comprises administering to such mammal an effective, TNF production inhibiting amount of a compound of Formula (I) as described herein. The compounds of Formula (II) are generally described as diaryl-substituted imidazole fused to a second heterocyclic ring containing a nitrogen bridgehead wherein said ring may also contain sulfur, oxygen, or an additional nitrogen atom, and may contain additional unsaturation.
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Inventors:
Badger, Allison Mary
Vendor, Paul Elliot
Esser, Claus Max
Griswold, Don Edgar
Hannah, Nabil
Lee, John Sea
Botta, Bartholomew Jude
Simon, Philip Leonard
Vendor, Paul Elliot
Esser, Claus Max
Griswold, Don Edgar
Hannah, Nabil
Lee, John Sea
Botta, Bartholomew Jude
Simon, Philip Leonard
Application Number:
JP51268490A
Publication Date:
June 24, 1993
Filing Date:
June 12, 1990
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORPORATION
International Classes:
A61K31/42; A61K31/425; A61K31/435; A61K31/44; A61K31/54; A61K31/55; A61P29/00; A61P43/00; C07D471/04; C07D487/04; C07D498/04; C07D513/04; (IPC1-7): A61K31/42; A61K31/425; A61K31/435; A61K31/54; A61K31/55; C07D471/04; C07D487/04; C07D498/04; C07D513/04
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)