【発明の名称】組換えDNAベクターを使用するヒトT細胞受容体要素に対するモノクローナル抗体の製造方法 - National Jewish Center For Immunology and Resparatory Medicine

Title:

【発明の名称】組換えDNAベクターを使用するヒトT細胞受容体要素に対するモノクローナル抗体の製造方法

Document Type and Number:

Japanese Patent JPH06502529

Kind Code:

A

Abstract:

Recombinant DNA vectors which express chimeric T cell receptors are disclosed. These chimeric T cell receptors contain one human element, and the rest of the elements are all of the same, non-human animal species, such as a mouse. Of particular interest are chimeras where the human element is V alpha or V beta . The vectors are used to transfect cells which derive from the same non-human animal species as the non-human animal species of the chimera, and the resulting transfectants are used to produce monoclonal antibodies against the human element of the chimera.

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Inventors:

Choi, Yongwon
John the coupler
Mallac, Filippa

Application Number:

JP51467391A

Publication Date:

March 24, 1994

Filing Date:

August 08, 1991

Export Citation:

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Assignee:

National Jewish Center For Immunology and Resparatory Medicine

International Classes:

C12N5/10; C07K14/72; C07K14/725; C07K16/28; C12N15/02; C12P21/08; (IPC1-7): C12P21/08; C12N5/10; C12N15/06

Attorney, Agent or Firm:

Akira Asamura (3 outside)

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