Title:
【発明の名称】バソプレッシン-およびバソトシン誘導体
Document Type and Number:
Japanese Patent JPH06504990
Kind Code:
A
Abstract:
PCT No. PCT/EP91/02496 Sec. 371 Date Jun. 22, 1993 Sec. 102(e) Date Dec. 20, 1993 PCT Filed Dec. 21, 1991 PCT Pub. No. WO92/11287 PCT Pub. Date Jul. 9, 1992.This invention relates to new vasopressin and vasotocin derivatives of general formula I in which A stands for the radical Mca (=3-mercapto-3,3-cyclpentamethylenepropionyl radical) or for the radical Mpa (=3-mercaptopropionyl radical), B stands for the amino acid radicals D-Tyr, D-Tyr(Et), D-Phe, Tyr(OMe), D-lle, D-Trp, or the radical of a hydrophobic D-amino acid, and C stands for phenylalanine (Phe; vasopressin derivatives) or isoleucine (lle; vasotocin derivatives). They have a high activity toward the oxytocin and the V-vasopressin receptors and can be used for the production of pharmaceutical agents.
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Inventors:
Vahrenholtz, Falk
Elgar, Walter
Fernrich, Marianne
Kvaritz, Krutztsov
Elgar, Walter
Fernrich, Marianne
Kvaritz, Krutztsov
Application Number:
JP50140892A
Publication Date:
June 09, 1994
Filing Date:
December 21, 1991
Export Citation:
Assignee:
Schering Aktiengesellschaft
International Classes:
A61K38/095; A61P1/16; C07K7/16; C07K14/575; A61K38/00; (IPC1-7): C07K7/16; A61K37/34
Attorney, Agent or Firm:
Toshio Yano (2 outside)