Title:
【発明の名称】イミダゾピリジンPAF/H↓1拮抗薬
Document Type and Number:
Japanese Patent JPH06504992
Kind Code:
A
Abstract:
PCT No. PCT/EP92/00163 Sec. 371 Date Jul. 12, 1993 Sec. 102(e) Date Jul. 12, 1993 PCT Filed Jan. 24, 1992 PCT Pub. No. WO92/14734 PCT Pub. Date Sep. 3, 1992.Compounds of formula (1), wherein X is CH or N; Z is CH=CH or S; A is CH2CH2, CH=CH, CH(OH)CH2, or COCH2; B is a direct link or -CH2-, -CH(CH3)- or -C(CH3)2-; or when Z is CH=CH, B may form a cyclopentane ring fused to the attached benzene ring; Y completes a fused benzo or thienyl ring which is optionally substituted by halo or C1-C4alkyl; n is 0, 1 or 2; and m is 0 or 1; are antagonists of both PAF and histamine H1 having utility in the treatment of allergic inflammatory conditions such as allergic rhinitis.
Inventors:
Alker, david
Bass, robert john
Kelvin, Cooper
Bass, robert john
Kelvin, Cooper
Application Number:
JP50350492A
Publication Date:
June 09, 1994
Filing Date:
January 24, 1992
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
A61K31/55; A61K31/437; A61K31/44; A61P11/00; A61P17/00; A61P37/08; A61P43/00; C07D211/68; C07D213/02; C07D221/04; C07D235/02; C07D335/02; C07D471/04; C07D519/00; (IPC1-7): C07D471/04; A61K31/55; C07D519/00
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)