Title:
【発明の名称】K-チャンネル遮断剤としてのピリミジン,シアノグアニジン
Document Type and Number:
Japanese Patent JPH08511264
Kind Code:
A
Abstract:
Pyrimidine-cyanoguanidine compounds of Formula (I) and its pharmaceutically acceptable acid addition salts wherein R1 is hydrogen or methyl; R2 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C5 cycloalkyl, C3-C5 cycloalkenyl, hydroxy methyl, methoxy C1-C5 alkyl, or R1 and R2 are combined to form a C3-C6 carbocyclic ring; R3 and R4 are each independently selected to be hydrogen, C1-C4 alkyl, F, Cl, Br, I or CF3; R5 is hydrogen, F or Cl; R6 is hydrogen, -NH2, -NHCH3, -NHC2H5, -NHCH(CH3)2, -N(CH3)2, -N(C2H5)2, NH(CH2)m-OC1-C3 alkyl (where m is 2 or 3), -NHC(O)C1-C3 alkyl, Cl or Br; and n is 0 or 1. The compounds of Formula I are potassium channel blockers useful in the treatment of cardiovascular disorders such as congestive heart failure and hypertension and as a diuretic.
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Inventors:
Humphrey, Stephen Jay
Meisheri, Corsic Dee
James Earl, Rudens
Hester, Jackson Bee Jr.
Meisheri, Corsic Dee
James Earl, Rudens
Hester, Jackson Bee Jr.
Application Number:
JP50171695A
Publication Date:
November 26, 1996
Filing Date:
November 26, 1993
Export Citation:
Assignee:
The Up John Company
International Classes:
A61K31/505; A61P7/10; A61P9/00; A61P9/08; A61P9/12; A61P13/02; A61P15/00; A61P43/00; C07D239/42; C07D239/48; (IPC1-7): C07D239/42; A61K31/505; C07D239/48
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)