Title:
骨質量疾患の診断、予防、及び治療方法
Document Type and Number:
Japanese Patent JP2011516486
Kind Code:
A
Abstract:
The present invention provides methods and therapeutic agents for lowering or increasing serum serotonin levels in a patient in order to increase or decrease bone mass, respectively. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteoporosis and the agents are TPH1 inhibitors or serotonin receptor antagonists.
Inventors:
Gerald Carsenti
Patricia F. Duchy
Yuri Sea
Donald Laundry
Vijay Yadaf
Patricia F. Duchy
Yuri Sea
Donald Laundry
Vijay Yadaf
Application Number:
JP2011503078A
Publication Date:
May 26, 2011
Filing Date:
March 30, 2009
Export Citation:
Assignee:
The Trustees of Columbia University in the City of New York
International Classes:
A61K45/00; A61K31/36; A61K31/4458; A61K31/472; A61K31/473; A61K31/4738; A61K31/505; A61K31/513; A61P19/08; A61P19/10; A61P25/24; A61P43/00
Foreign References:
| WO2007089335A2 | 2007-08-09 | |||
| US20070127573A1 | 2007-06-07 | |||
| WO2007060408A2 | 2007-05-31 |
Other References:
JPN6013040582; ＬＩＵ，Ｑ． ｅｔ ａｌ: ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＰＨＡＲＭＡＣＯＬＯＧＹ ＡＮＤ ＥＸＰＥＲＩＭＥＮＴＡＬ ＴＨＥＲＡＰＥＵＴＩＣＳ Ｖｏｌ．３２５， Ｎｏ．１, 2007, ｐ．４７-５５
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro