Title:
【発明の名称】イミダゾ〔1,5-a〕インドール-3-オンのイミダゾリルアルキル誘導体およびそれらの製造法
Document Type and Number:
Japanese Patent JPH09500912
Kind Code:
A
Abstract:
PCT No. PCT/EP95/01651 Sec. 371 Date Jan. 24, 1996 Sec. 102(e) Date Jan. 24, 1996 PCT Filed May 2, 1995 PCT Pub. No. WO95/32204 PCT Pub. Date Nov. 30, 1995Novel 5-HT3 receptor antagonist compounds having following formula (I) (I) wherein n is 1, 2 or 3; each of R, R1 and R2, which may be the same or different, is hydrogen, halogen, hydroxy, cyano, C1-C6 alkyl, CF3, C1-C6 alkoxy, C1-C6 alkylthio, formyl, C2-C6 alkanoyl, carboxy, C1-C6 alkoxy-carbonyl, nitro, -N (R4 R5) in which each of R4 and R5 independently is hydrogen, C1-C6 alkyl, formyl or C2-C6 alkanoyl; or a (R6 R7) N-SO2 group, in which each of R6 and R7 independently is hydrogen or C1-C6 alkyl; R3 is an imidazolyl group of formula wherein each of R8 and R10 which may be the same or different is hydrogen or C1-C6 alkyl, R9 is hydrogen, C1-C6 alkyl or a nitrogen protecting group; and the pharmaceutically acceptable salts thereof, are disclosed.
Inventors:
Barashi, Mario
Haydem Persian, Franco
Carthia, carla
Salvation, Patricia
Haydem Persian, Franco
Carthia, carla
Salvation, Patricia
Application Number:
JP53000995A
Publication Date:
January 28, 1997
Filing Date:
May 02, 1995
Export Citation:
Assignee:
Falmatia Esset Pear
International Classes:
A61K31/415; A61K31/4188; A61P1/00; A61P1/08; A61P1/12; A61P25/06; A61P25/18; A61P25/22; A61P25/28; A61P25/36; A61P43/00; C07D487/04; (IPC1-7): C07D487/04; A61K31/415
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)